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Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance

Overview of attention for article published in Arthritis Research & Therapy, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
9 tweeters

Citations

dimensions_citation
118 Dimensions

Readers on

mendeley
117 Mendeley
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Title
Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
Published in
Arthritis Research & Therapy, January 2012
DOI 10.1186/ar3874
Pubmed ID
Authors

Ilias Stagakis, George Bertsias, Stylianos Karvounaris, Melina Kavousanaki, Dimitra Virla, Amalia Raptopoulou, Dimitrios Kardassis, Dimitrios T Boumpas, Prodromos I Sidiropoulos

Abstract

Prevalence of insulin resistance and the metabolic syndrome has been reported to be high in rheumatoid arthritis (RA) patients. Tumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogenetic role in RA, may promote insulin resistance by inducing Ser312 phosphorylation (p-Ser312) of insulin receptor substrate (IRS)-1 and downregulating phosphorylated (p-)AKT. We examined whether anti-TNF therapy improves insulin resistance in RA patients and assessed changes in the insulin signaling cascade.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Russia 1 <1%
Brazil 1 <1%
Unknown 112 96%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 17 15%
Student > Ph. D. Student 14 12%
Student > Master 13 11%
Student > Bachelor 11 9%
Researcher 9 8%
Other 32 27%
Unknown 21 18%
Readers by discipline Count As %
Medicine and Dentistry 55 47%
Pharmacology, Toxicology and Pharmaceutical Science 8 7%
Agricultural and Biological Sciences 8 7%
Biochemistry, Genetics and Molecular Biology 5 4%
Nursing and Health Professions 5 4%
Other 8 7%
Unknown 28 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2012.
All research outputs
#4,839,530
of 20,223,269 outputs
Outputs from Arthritis Research & Therapy
#1,068
of 2,774 outputs
Outputs of similar age
#32,204
of 140,540 outputs
Outputs of similar age from Arthritis Research & Therapy
#2
of 5 outputs
Altmetric has tracked 20,223,269 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,774 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.