Title |
Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study
|
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Published in |
BMC Neurology, June 2012
|
DOI | 10.1186/1471-2377-12-36 |
Pubmed ID | |
Authors |
Patrick Vermersch, Rabah Benrabah, Nicolas Schmidt, Hélène Zéphir, Pierre Clavelou, Cyrille Vongsouthi, Patrice Dubreuil, Alain Moussy, Olivier Hermine |
Abstract |
Treatment options for patients suffering from progressive forms of multiple sclerosis (MS) remain inadequate. Mast cells actively participate in the pathogenesis of MS, in part because they release large amounts of various mediators that sustain the inflammatory network. Masitinib, a selective oral tyrosine kinase inhibitor, effectively inhibits the survival, migration and activity of mast cells. This exploratory study assessed the safety and clinical benefit of masitinib in the treatment of primary progressive MS (PPMS) or relapse-free secondary progressive MS (rfSPMS). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Egypt | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Spain | 1 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 131 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 15% |
Student > Ph. D. Student | 19 | 14% |
Unspecified | 12 | 9% |
Student > Bachelor | 12 | 9% |
Student > Master | 9 | 7% |
Other | 38 | 28% |
Unknown | 25 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 26% |
Neuroscience | 14 | 10% |
Unspecified | 12 | 9% |
Agricultural and Biological Sciences | 11 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 25 | 18% |
Unknown | 32 | 24% |