Title |
Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus
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Published in |
Retrovirology, May 2012
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DOI | 10.1186/1742-4690-9-48 |
Pubmed ID | |
Authors |
Hazel Stewart, Karen W Adema, Elizabeth L McMonagle, Margaret J Hosie, Brian J Willett |
Abstract |
The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycoprotein that result in a shift in the receptor usage and the cell tropism of the virus. The factors that influence the transition from subgroup A to subgroup C remain unclear, one possibility is that a selective pressure in the host drives the acquisition of mutations in the RBD, creating A/C intermediates with enhanced abilities to interact with the FeLV-C receptor, FLVCR. In order to understand further the emergence of FeLV-C in the infected cat, we examined primary isolates of FeLV-C for evidence of FeLV-A variants that bore mutations consistent with a gradual evolution from FeLV-A to FeLV-C. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Switzerland | 1 | 2% |
Austria | 1 | 2% |
Unknown | 38 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 15% |
Student > Doctoral Student | 6 | 15% |
Student > Bachelor | 6 | 15% |
Other | 3 | 7% |
Student > Ph. D. Student | 3 | 7% |
Other | 12 | 29% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 13 | 32% |
Veterinary Science and Veterinary Medicine | 11 | 27% |
Medicine and Dentistry | 6 | 15% |
Immunology and Microbiology | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 0 | 0% |
Unknown | 6 | 15% |