Title |
Stable stem enabled Shannon entropies distinguish non-coding RNAs from random backgrounds
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Published in |
BMC Bioinformatics, April 2012
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DOI | 10.1186/1471-2105-13-s5-s1 |
Pubmed ID | |
Authors |
Yingfeng Wang, Amir Manzour, Pooya Shareghi, Timothy I Shaw, Ying-Wai Li, Russell L Malmberg, Liming Cai |
Abstract |
The computational identification of RNAs in genomic sequences requires the identification of signals of RNA sequences. Shannon base pairing entropy is an indicator for RNA secondary structure fold certainty in detection of structural, non-coding RNAs (ncRNAs). Under the Boltzmann ensemble of secondary structures, the probability of a base pair is estimated from its frequency across all the alternative equilibrium structures. However, such an entropy has yet to deliver the desired performance for distinguishing ncRNAs from random sequences. Developing novel methods to improve the entropy measure performance may result in more effective ncRNA gene finding based on structure detection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 10% |
France | 1 | 10% |
Canada | 1 | 10% |
Unknown | 7 | 70% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 40% |
Student > Master | 2 | 20% |
Student > Ph. D. Student | 1 | 10% |
Student > Doctoral Student | 1 | 10% |
Professor > Associate Professor | 1 | 10% |
Other | 0 | 0% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
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Computer Science | 4 | 40% |
Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Immunology and Microbiology | 2 | 20% |
Agricultural and Biological Sciences | 1 | 10% |
Unknown | 1 | 10% |