Title |
Bacteria in cancer therapy: a novel experimental strategy
|
---|---|
Published in |
Journal of Biomedical Science, March 2010
|
DOI | 10.1186/1423-0127-17-21 |
Pubmed ID | |
Authors |
S Patyar, R Joshi, DS Prasad Byrav, A Prakash, B Medhi, BK Das |
Abstract |
Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need of alternative cancer therapies. Moreover, the success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity to normal tissues. Several decades after Coley's work a variety of natural and genetically modified non-pathogenic bacterial species are being explored as potential antitumor agents, either to provide direct tumoricidal effects or to deliver tumoricidal molecules. Live, attenuated or genetically modified non-pathogenic bacterial species are capable of multiplying selectively in tumors and inhibiting their growth. Due to their selectivity for tumor tissues, these bacteria and their spores also serve as ideal vectors for delivering therapeutic proteins to tumors. Bacterial toxins too have emerged as promising cancer treatment strategy. The most potential and promising strategy is bacteria based gene-directed enzyme prodrug therapy. Although it has shown successful results in vivo yet further investigation about the targeting mechanisms of the bacteria are required to make it a complete therapeutic approach in cancer treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | <1% |
United States | 2 | <1% |
Brazil | 2 | <1% |
Portugal | 1 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
Malaysia | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Other | 2 | <1% |
Unknown | 534 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 119 | 22% |
Student > Master | 93 | 17% |
Student > Bachelor | 85 | 16% |
Researcher | 61 | 11% |
Student > Postgraduate | 23 | 4% |
Other | 68 | 12% |
Unknown | 99 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 160 | 29% |
Biochemistry, Genetics and Molecular Biology | 116 | 21% |
Medicine and Dentistry | 41 | 7% |
Immunology and Microbiology | 38 | 7% |
Engineering | 19 | 3% |
Other | 55 | 10% |
Unknown | 119 | 22% |