Title |
Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis
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Published in |
Alzheimer's Research & Therapy, June 2012
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DOI | 10.1186/alzrt124 |
Pubmed ID | |
Authors |
Amanda Hanna, Kayleigh Iremonger, Pritam Das, Dennis Dickson, Todd Golde, Christopher Janus |
Abstract |
The current pathological confirmation of the diagnosis of Alzheimer's disease (AD) is still based on postmortem identification of parenchymal amyloid beta (Aβ) plaques, intra-neuronal neurofibrillary tangles, and neuronal loss. The memory deficits that are present in the early stages of AD are linked to the dysfunction of structures in the entorhinal cortex and limbic system, especially the hippocampus and amygdala. Using the CRND8 transgenic mouse model of amyloidosis, which over-expresses a mutant human amyloid precursor protein (APP) gene, we evaluated hippocampus-dependent contextual and amygdala-dependent tone fear conditioned (FC) memory, and investigated the relationship between the fear memory indices and Aβ plaque burden. |
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Mendeley readers
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Demographic breakdown
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Student > Bachelor | 5 | 13% |
Researcher | 5 | 13% |
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Professor > Associate Professor | 3 | 8% |
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Nursing and Health Professions | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 25% |