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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients
|
|---|---|
| Published in |
Critical Care, June 2012
|
| DOI | 10.1186/cc11391 |
| Pubmed ID | |
| Authors |
John W Pickering, Christopher M Frampton, Robert J Walker, Geoffrey M Shaw, Zoltán H Endre |
| Abstract |
ABSTRACT: INTRODUCTION: Acute kidney injury (AKI) diagnosis is based on an increase in plasma creatinine, which is a slowly changing surrogate of decreased glomerular filtration rate. We investigated whether serial creatinine clearance, a direct measure of the glomerular filtration rate, provided more timely and accurate information on renal function than serial plasma creatinine in critically ill patients. METHODS: Serial plasma creatinine and 4-hour creatinine clearance were measured 12-hourly for 24 hours and then daily in 484 patients. AKI was defined either as > 50% increase in plasma creatinine from baseline, or > 33.3% decrease in creatinine clearance. The diagnostic and predictive performance of the two AKI definitions were compared. RESULTS: Creatinine clearance decrease diagnosed AKI in 24% of those not diagnosed by plasma creatinine increase on entry. These patients entered the ICU sooner after insult than those diagnosed with AKI by plasma creatinine elevation (P = 0.0041). Mortality and dialysis requirement increased with the change in creatinine clearance-acute kidney injury severity class (P = 0.0021). Amongst patients with plasma creatinine < 1.24 mg/dl on entry, creatinine clearance improved the prediction of AKI considerably (Net Reclassification Improvement 83%, Integrated Discrimination Improvement 0.29). On-entry, creatinine clearance associated with AKI severity and duration (P < 0.0001) predicted dialysis need (area under the curve: 0.75) and death (0.61). A > 33.3% decrease in creatinine clearance over the first 12 hours was associated with a 2.0-fold increased relative risk of dialysis or death. CONCLUSIONS: Repeated 4-hour creatinine clearance measurements in critically ill patients allow earlier detection of AKI, as well as progression and recovery compared to plasma creatinine. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN012606000032550. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kuwait | 1 | 17% |
| Japan | 1 | 17% |
| Spain | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| South Africa | 1 | <1% |
| Czechia | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 105 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 17 | 15% |
| Researcher | 15 | 13% |
| Student > Postgraduate | 9 | 8% |
| Student > Bachelor | 8 | 7% |
| Student > Ph. D. Student | 7 | 6% |
| Other | 29 | 26% |
| Unknown | 28 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 59 | 52% |
| Agricultural and Biological Sciences | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 32 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2021.
All research outputs
#2,857,436
of 25,374,917 outputs
Outputs from Critical Care
#2,445
of 6,554 outputs
Outputs of similar age
#17,968
of 177,907 outputs
Outputs of similar age from Critical Care
#13
of 127 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,907 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.