Title |
Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009
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Published in |
Virology Journal, June 2012
|
DOI | 10.1186/1743-422x-9-125 |
Pubmed ID | |
Authors |
Tao Jiang, Xue-Dong Yu, Wen-Xin Hong, Wei-Ze Zhou, Man Yu, Yong-Qiang Deng, Shun-Ya Zhu, E-De Qin, Jian Wang, Cheng-Feng Qin, Fu-Chun Zhang |
Abstract |
Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Unknown | 51 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 19% |
Student > Master | 9 | 17% |
Student > Ph. D. Student | 7 | 13% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Other | 8 | 15% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 15 | 28% |
Medicine and Dentistry | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Immunology and Microbiology | 3 | 6% |
Chemistry | 2 | 4% |
Other | 6 | 11% |
Unknown | 11 | 21% |