RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
RT @SeekingTruth4us: @Fynnderella1 🤔Endless risky💉💉😷or PRN safe #EarlyTreatmentWorks https://t.co/XXYYrPGrN6 https://t.co/77kO850Cro
RT @SeekingTruth4us: @Fynnderella1 🤔Endless risky💉💉😷or PRN safe #EarlyTreatmentWorks https://t.co/XXYYrPGrN6 https://t.co/77kO850Cro
@Fynnderella1 🤔Endless risky💉💉😷or PRN safe #EarlyTreatmentWorks https://t.co/XXYYrPGrN6 https://t.co/77kO850Cro
RT @SeekingTruth4us: @RobertKennedyJr @AaronSiriSG 👏#Placebo control is to isolate experimental variable in experimental group from control…
RT @SeekingTruth4us: @RobertKennedyJr @AaronSiriSG 👏#Placebo control is to isolate experimental variable in experimental group from control…
@RobertKennedyJr @AaronSiriSG 👏#Placebo control is to isolate experimental variable in experimental group from control group (if needed both groups could get same non-experimental standard care) 🤔Why punish MDs who report superior outcomes for control gro
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
@Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as well as 💉adverse effects https://t.co/0G252oxyg2 with NO sterilizing immunity "still had high levels of virus replicating in their upper
RT @dreamgbutterfly: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
@Daoyu15 @lissnup @KeithEv84928885 @breakfast_dogs IMO, it is a problem of selective infection by countries faced globally. https://t.co/kbvyV5ApP4
@thirdeyemafia @yessss44941792 "Virus mutagenic capability depends upon several factors, including the fidelity of viral enzymes that replicate nucleic acids, as SARS-CoV-2 RNA dependent RNA polymerase (RdRp)." https://t.co/vZKoYzMpK5
4 mai 2020 https://t.co/7fNFQ0j0D9
RT @statesdj: @macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on it…
RT @statesdj: @macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on it…
@macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on its own https://t.co/WE7fAzsLtF
@SchreiberStuart @michaelzlin SARS-CoV-2 polymerase makes ~an error/genome copy. COVID cases cough out millions of mutated progeny all the time, and there are mutator pol mutants that increase the error rate. Using nucleoside analogs isn’t going to add sig
@CurlyJungleJake SARS-CoV-2 polymerase makes ~an error/genome copy. COVID cases already cough out millions of progeny with every base in the genome mutated, and there are mutator mutants that increase polymerase error rate. Virus doesn’t need help to gener
@FlaviusEye @Bhedin7 @SaskLass @Walmart @WalmartCanada They say they sequence some suspected delta. The virus has never been electron microscoped as far as I can find. It's been sequenced and in January 2020 there was already numerous mutations. This is a
RT @dreamgbutterfly: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
@LuxorSabatini Ti manca la comprensione di cosa sia un articolo scientifico. Sei evidentemente un troll il cui unico scopo è far perdere tempo. Bye https://t.co/OYwQKV7ngM
@Raphque @JanJambon Als LEGO niet goed genoeg is voor meneer. https://t.co/ibkPHIrYlx Lees een beetje over fenotypische plasticiteit en waarom het gaat over de hoeveelheid virus op de wereld zo rap mogelijk zo laag mogelijk krijgen. Een volgende mutatie
$ADMP and #DeltaVariant :
@hjelle_brian This is interesting https://t.co/6czXiC2eiq
If you invest in #COVID19 treatments - you Must get this ⬇️ $ADMP $MRK
RT @AlphaTrader00: As always, This guy really gets it! 👇 $ADMP's Tempol targets RNA Replicase which is as #VariantAgnostic as you are goin…
As always, This guy really gets it! 👇 $ADMP's Tempol targets RNA Replicase which is as #VariantAgnostic as you are going to get for an anti-viral orally administered preventative/therapeutic
$ADMP hits variants - improvement on $MRK
$MRK Molnupiravir targets SARSCoV2 RNA Polymerase https://t.co/UB88cP8iaY Which makes it prone to variant mutation - its P3 on Wild type virus is not applicable to Delta Variant https://t.co/KL55twIufO $ADMP Tempol hits Replicase - very stable - applies t
Sdeng!!!
@MLevitt_NP2013 Thanks for the Structural Biology PNAS paper. I read it and it is very interesting. A recent variant emerged with a polymerase mutation. Also, I'd also like to know how cov2's RBD has changed in stability in interaction with human ACE2 ov
RT @Nic_Trevi: Qui lo studio https://t.co/T8ckTyKl37
Qui lo studio https://t.co/T8ckTyKl37
RT @cesarcuadra: Lamentablemente, esto NO es cierto. Se han encontrado mutaciones en todos los genes del SARS-CoV-2, hay muchos reportes al…
Lamentablemente, esto NO es cierto. Se han encontrado mutaciones en todos los genes del SARS-CoV-2, hay muchos reportes al respecto en medline. Por ejemplo este: mutacion en el gen de la RdRP https://t.co/bPxkOWlIff
@CliveWismayer coronaviruses are known for their rapid mutability , but here's a scientific paper from April 2020 mentioning 220 variants of the "Wuhan seafood market pneumonia virus" logged Dec19 to March20. https://t.co/CUxifCGsxe
@CliveWismayer Just in case this is serious, here's an example. April 2020, science world all over the mutations. https://t.co/X8xV38wto5
@CliveWismayer SARS-CoV-2 is a RNA #Coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome #COVID19. RNA VIRUSES ARE CHARACTERISED BY A HIGH MUTATION RATE. https://t.co/loZGQzQxlO
Perfect. Thank you.
Sars from the bottom up https://t.co/tHJ11g7sOF
N.B.: J'avais prédit tout ça au mois de mai... https://t.co/7fNFQ0j0D9
@gsgs2 Don’t like this table at all. Why are all the mutations in Europe? #b117 https://t.co/IOyaujbflV https://t.co/ofROA1Ex3g
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant - PubMed Si sus familiares son médicos, saben dónde investigar , los 🦠 todos mutan , millones.Humanos 2 mutaciones 🧬,en AR , pble Diana 🎯 tx https://t.co/rep55AlBg
RT @Antagoniste_net: 1/ SARS-CoV-2 est un virus à ARN. Normalement les virus à ARN (comme influenza), mutent beaucoup. Pour SARS-CoV-2, i…
RT @Antagoniste_net: Série de tweets que j'ai écrit le 4 mai... https://t.co/GntS2i0u2w
RT @Antagoniste_net: Série de tweets que j'ai écrit le 4 mai... https://t.co/GntS2i0u2w
RT @Antagoniste_net: Série de tweets que j'ai écrit le 4 mai... https://t.co/GntS2i0u2w
Série de tweets que j'ai écrit le 4 mai... https://t.co/GntS2i0u2w
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
Over time, different #virus strains in the same host end up inhibiting each other to diminish lethality and increase spread. Mutations in NSP create a equilibrium in infection/death. #SARSCoV2 #covid19 https://t.co/5qcP47ofAf
@MattLech @jamescphipps1 @karenkho This paper describes 3 variants caused by mutation in Asia, Europe, and North America so it doesn’t look like that’s going to be the case. We don’t know. One of the vaccines in trial attacks the crowns of the virus which
Emerging SARS-CoV-2 mutation hot Open Access Journal of Translational Medicine spots include a novel RNA-dependent-RNA polymerase variant https://t.co/YC4ES4YSTA
@CentristAllWay @debhodges1413 Here is a study on variants: These findings suggest that the virus is evolving and European, North American and Asian strains might coexist, each of them characterized by a different mutation pattern. https://t.co/svF4EoeaPT
@Shanbeleeleh @Mahooolak با توجه به این مقاله، ساخت واکسن باید خیلی سخت باشه. https://t.co/Vsrdp60eOw
@meteorologo777 Il virus é mutato, c'é un'ampia bibliografia che lo dimostra https://t.co/H0kbNwraZn l'affermazione contestata da alcuni virologi riguarda l'attenuazione della carica virale. Attualmente esiste un lavoro solido effettuato da ricercatori ci
RT @Rossana38510044: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/xWjxr9Wycw
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/xWjxr9Wycw
@KielyNeil @MaxChesnes You are right. If a person isolates themself, they will not contract the virus, however isolation is not sustainable. This virus is going nowhere and its mutation rate will most likely render a vaccine useless. Have you ever had a co
RT @Atomoxetina: FUENTE: Pachetti, M., Marini, B., Benedetti, F. et al. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-depende…
FUENTE: Pachetti, M., Marini, B., Benedetti, F. et al. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J Transl Med 18, 179 (2020). https://t.co/q9NhAlTFJe
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
@peripatetical Thanks heaps. It appears 2018/19 samples not tested rather used as controls? may explain the low sensitivity? Also "all +ve samples had SARS-CoV-2 .. conducted.. assay for the.. RdRp gene"....some debate about non silent mutations(pos 14
@pinkzebracross @MLevitt_NP2013 in most countries isolates were found, i think, but you ask for published papers: Mutation Hotspots https://t.co/w7o9kezDb9 Italy : https://t.co/GF4XN4IQWW Europe https://t.co/huk1gxnX4A Iceland https://t.co/uhJsdZRUJa
I spoke to someone who claimed they were a physician that said “this Virus (CoV-SARS-2) doesn’t mutate like the flu, the media is just playing this up” https://t.co/O0DfNbydGv
@ROMANOVNICOLAI @VirtualRaven @chetempochefa @RobertoBurioni @fabfazio E dal momento che sono abituato a parlare sui dati, e non sulle fantasie, le lascio il link dove si evidenzia la scarsa mutabilità della spike. Un solo ceppo con spike mutata, e per un
@luigi_warren @BillyBostickson @_coltseavers @paleovanguard @relluminati1 @R_H_Ebright @Harvard2H There is at least one mutation already described in the RdRp region of SARS-CoV-2. https://t.co/n45xhFd1wE https://t.co/x5KwmZ8WFy
RT @FerSuarezMD: Aqui el gráfico comparativo, abajo el enlace al artículo https://t.co/mQsh7SC10X https://t.co/qErDLewaBx
RT @FerSuarezMD: Aqui el gráfico comparativo, abajo el enlace al artículo https://t.co/mQsh7SC10X https://t.co/qErDLewaBx
Aqui el gráfico comparativo, abajo el enlace al artículo https://t.co/mQsh7SC10X https://t.co/qErDLewaBx
Mutations in the S protein of SARS-CoV-2 raises concerns about the efficacy of a S protein-based vaccine (https://t.co/plTjUgZaib - https://t.co/R2d38jXd9e). Moving one step ahead of SARS-CoV-2, researchers suggest identification of potential human ACE2
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. https://t.co/xYWi5ur7mu Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P, Masciovecchio C, Angeletti S, Ciccozzi M, Gallo RC, Zella D, Ippodrino R
@_atanas_ SARS-CoV-2 mutates much slower than seasonal Flu (https://t.co/kUx9SjrkjO) and SARS (https://t.co/plTjUgZaib). The SARS-CoV-2 genomes from European and North American patients with #COVID19 present an increase in mutation frequency compared to As
The SARS-CoV-2 genomes from European and North American patients with #COVID19 present an increase in mutation frequency compared to Asia. https://t.co/R2d38jXd9e https://t.co/rjT32xWWua
RT @BlueJayGliding: This is moderately terrifying... Three distinct strains of SARS-COVID-2 identified in different locations. The last vir…
@aciscokid @DianeRo25123293 @ClimateAudit @johnrobertsFox @nerdhaspower Actually, many mutations have already been detected in SARS-CoV-2, even in the RdRp region. And many more go undetected, of course. Anyway, that was not the point of this thread, so I
@TheAtlantic @jameshamblin @katlwells @edyong209 Here is another very interesting study SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of #COVID19. RNA viruses are characterized by a high mutation rate, up to a million times higher than that
RT @mbalsevich: @tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se está…
RT @mbalsevich: @tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se está…
@tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se están publicando en varias fuentes que creo respetables: https://t.co/RNzs9FkrEg
@SamAdamsLPL @NelsonDaleSmith @BillHanage @hbdchick HIV mutates to multiple different viral phenotypes, *in each host*. The ORF1b P314L mutant (in the RdRp) has been associated with larger numbers of genomic substitutions. https://t.co/gRpKRKb0Co 1/2 h