Title |
A neurochemical map of the developing amphioxus nervous system
|
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Published in |
BMC Neuroscience, June 2012
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DOI | 10.1186/1471-2202-13-59 |
Pubmed ID | |
Authors |
Simona Candiani, Luca Moronti, Paola Ramoino, Michael Schubert, Mario Pestarino |
Abstract |
Amphioxus, representing the most basal group of living chordates, is the best available proxy for the last invertebrate ancestor of the chordates. Although the central nervous system (CNS) of amphioxus comprises only about 20,000 neurons (as compared to billions in vertebrates), the developmental genetics and neuroanatomy of amphioxus are strikingly vertebrate-like. In the present study, we mapped the distribution of amphioxus CNS cells producing distinctive neurochemicals. To this end, we cloned genes encoding biosynthetic enzymes and/or transporters of the most common neurotransmitters and assayed their developmental expression in the embryo and early larva. |
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Demographic breakdown
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Mendeley readers
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