Title |
Pro-inflammatory genetic profile and familiarity of acute myocardial infarction
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Published in |
Immunity & Ageing, June 2012
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DOI | 10.1186/1742-4933-9-14 |
Pubmed ID | |
Authors |
Manuela Ianni, Sergio Callegari, Antonio Rizzo, Paolo Pastori, Paolo Moruzzi, Domenico Corradi, Elisa Porcellini, Gianluca Campo, Roberto Ferrari, Marco M Ferrario, Stefania Bitonte, Ilaria Carbone, Federico Licastro |
Abstract |
Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory responses are implicated in the pathogenesis of atherosclerosis and a premature AMI of parents is associated with an increased risk of the disease in their offspring (Offs). However, the genetic background of familiarity for AMI is still largely unknown. To understand which genes may predispose to increased risk of cardiovascular disease gene polymorphism of immune regulatory genes, and clinical events from the Offs of parents with an early AMI were investigated. Genetics data from Offs were compared with those obtained from healthy subjects and an independent cohort of patients with clinical sporadic AMI. Rates of clinical events during a 24 years follow up from Offs and from an independent Italian population survey were also evaluated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 15% |
Student > Postgraduate | 3 | 12% |
Professor > Associate Professor | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Bachelor | 2 | 8% |
Other | 9 | 35% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 46% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
Agricultural and Biological Sciences | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 5 | 19% |