Title |
Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis
|
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Published in |
Journal of Neuroinflammation, June 2012
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DOI | 10.1186/1742-2094-9-139 |
Pubmed ID | |
Authors |
Nicolás Fissolo, Carme Costa, Ramil N Nurtdinov, Marta F Bustamante, Victor Llombart, María J Mansilla, Carmen Espejo, Xavier Montalban, Manuel Comabella |
Abstract |
DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely unknown. Here, we aimed to expand previous knowledge existing on the mechanisms of action of DNA vaccines in the animal model of MS, experimental autoimmune encephalomyelitis (EAE), by treating EAE mice with a DNA vaccine encoding the myelin oligodendrocyte glycoprotein (MOG), and exploring the therapeutic effects on the disease-induced inflammatory and neurodegenerative changes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 27% |
Researcher | 11 | 18% |
Student > Master | 10 | 17% |
Student > Postgraduate | 3 | 5% |
Student > Bachelor | 2 | 3% |
Other | 10 | 17% |
Unknown | 8 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 20% |
Agricultural and Biological Sciences | 11 | 18% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Neuroscience | 8 | 13% |
Nursing and Health Professions | 2 | 3% |
Other | 7 | 12% |
Unknown | 12 | 20% |