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Suppression of neuropeptide production by quercetin in allergic rhinitis model rats

Overview of attention for article published in BMC Complementary and Alternative Medicine, May 2016
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2 tweeters

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18 Dimensions

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30 Mendeley
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Title
Suppression of neuropeptide production by quercetin in allergic rhinitis model rats
Published in
BMC Complementary and Alternative Medicine, May 2016
DOI 10.1186/s12906-016-1123-z
Pubmed ID
Authors

Misako Kashiwabara, Kazuhito Asano, Tomomi Mizuyoshi, Hitome Kobayashi

Abstract

Quercetin, a dietary flavonoid found in many fruits, red wine and onion, among others, has been reported to have potent anti-oxidant, anti-viral and anti-cancer effects. Although quercetin is also reported to have anti-inflammatory and anti-allergic effects, the precise mechanisms by which quercetin favorably modify the clinical conditions of allergic diseases such as allergic rhinitis (AR). The present study was designed to examine the influence of quercetin on the development of AR by using AR model rats. Sprague-Dawley (SD) rats were sensitized with toluene 2,4-diisocyanate (TDI) by intranasal instillation of a 10 % TDI in ethyl acetate in a volume of 5 μl once a day for 5 consecutive days. This sensitization procedure was repeated after a 2-day interval. After 5 days of the second sensitization, rats were treated with various doses of quercetin once a day for 2 to 7 days. Nasal allergy-like symptoms, which were induced by bilateral application of 5 μl of 10 % TDI in ethyl acetate, were assessed by counting sneezing and nasal rubbing behaviors for 10 min just after TDI nasal challenge. The levels of substance P (SP), calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF) in nasal lavage fluids obtained 6 h after TDI nasal challenge was examined by ELISA. Oral administration of quercetin for 5 and 7 days, but not 2 and 3 days, could inhibit sneezing and nasal rubbing movements, which were increased by TDI nasal challenge. The minimum dose that caused significant inhibition was 25 mg/kg. Oral administration of quercetin at more than 25 mg/kg for 5 days significantly inhibited the increase in SP, CGRP and NGF contents in nasal lavage fluids induced by TDI nasal challenge. The present results strongly suggested that quercetin will be a good candidate for the supplement on the management and treatment of allergic diseases, especially AR.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 30%
Student > Bachelor 7 23%
Other 2 7%
Student > Master 2 7%
Professor 1 3%
Other 3 10%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 7 23%
Agricultural and Biological Sciences 3 10%
Nursing and Health Professions 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Immunology and Microbiology 2 7%
Other 5 17%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2016.
All research outputs
#3,783,330
of 7,729,992 outputs
Outputs from BMC Complementary and Alternative Medicine
#970
of 1,932 outputs
Outputs of similar age
#133,670
of 268,456 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#21
of 40 outputs
Altmetric has tracked 7,729,992 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,932 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,456 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.