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Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

Overview of attention for article published in Journal of Translational Medicine, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

blogs
2 blogs
twitter
16 tweeters
facebook
2 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor
video
2 video uploaders

Citations

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76 Dimensions

Readers on

mendeley
96 Mendeley
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Title
Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
Published in
Journal of Translational Medicine, August 2011
DOI 10.1186/1479-5876-9-129
Pubmed ID
Authors

Shaheen E Lakhan, Annette Kirchgessner

Abstract

Cigarette smoke is a major risk factor for a number of diseases including lung cancer and respiratory infections. Paradoxically, it also contains nicotine, an anti-inflammatory alkaloid. There is increasing evidence that smokers have a lower incidence of some inflammatory diseases, including ulcerative colitis, and the protective effect involves the activation of a cholinergic anti-inflammatory pathway that requires the α7 nicotinic acetylcholine receptor (α7nAChR) on immune cells. Obesity is characterized by chronic low-grade inflammation, which contributes to insulin resistance. Nicotine significantly improves glucose homeostasis and insulin sensitivity in genetically obese and diet-induced obese mice, which is associated with suppressed adipose tissue inflammation. Inflammation that results in disruption of the epithelial barrier is a hallmark of inflammatory bowel disease, and nicotine is protective in ulcerative colitis. This article summarizes current evidence for the anti-inflammatory effects of nicotine in obesity and ulcerative colitis. Selective agonists for the α7nAChR could represent a promising pharmacological strategy for the treatment of inflammation in obesity and ulcerative colitis. Nevertheless, we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 25%
Student > Bachelor 12 13%
Professor > Associate Professor 10 10%
Student > Ph. D. Student 8 8%
Researcher 6 6%
Other 17 18%
Unknown 19 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 24%
Medicine and Dentistry 23 24%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Nursing and Health Professions 5 5%
Immunology and Microbiology 4 4%
Other 15 16%
Unknown 20 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2021.
All research outputs
#960,892
of 18,694,771 outputs
Outputs from Journal of Translational Medicine
#161
of 3,348 outputs
Outputs of similar age
#5,858
of 136,707 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
Altmetric has tracked 18,694,771 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,348 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,707 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them