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Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

Overview of attention for article published in Journal of Translational Medicine, August 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
39 X users
facebook
2 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor
video
1 YouTube creator

Citations

dimensions_citation
97 Dimensions

Readers on

mendeley
119 Mendeley
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Title
Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
Published in
Journal of Translational Medicine, August 2011
DOI 10.1186/1479-5876-9-129
Pubmed ID
Authors

Shaheen E Lakhan, Annette Kirchgessner

Abstract

Cigarette smoke is a major risk factor for a number of diseases including lung cancer and respiratory infections. Paradoxically, it also contains nicotine, an anti-inflammatory alkaloid. There is increasing evidence that smokers have a lower incidence of some inflammatory diseases, including ulcerative colitis, and the protective effect involves the activation of a cholinergic anti-inflammatory pathway that requires the α7 nicotinic acetylcholine receptor (α7nAChR) on immune cells. Obesity is characterized by chronic low-grade inflammation, which contributes to insulin resistance. Nicotine significantly improves glucose homeostasis and insulin sensitivity in genetically obese and diet-induced obese mice, which is associated with suppressed adipose tissue inflammation. Inflammation that results in disruption of the epithelial barrier is a hallmark of inflammatory bowel disease, and nicotine is protective in ulcerative colitis. This article summarizes current evidence for the anti-inflammatory effects of nicotine in obesity and ulcerative colitis. Selective agonists for the α7nAChR could represent a promising pharmacological strategy for the treatment of inflammation in obesity and ulcerative colitis. Nevertheless, we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell.

X Demographics

X Demographics

The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 119 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 20%
Student > Bachelor 13 11%
Professor > Associate Professor 10 8%
Student > Ph. D. Student 10 8%
Researcher 7 6%
Other 19 16%
Unknown 36 30%
Readers by discipline Count As %
Medicine and Dentistry 26 22%
Agricultural and Biological Sciences 22 18%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Nursing and Health Professions 5 4%
Chemistry 5 4%
Other 17 14%
Unknown 37 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#865,144
of 25,402,889 outputs
Outputs from Journal of Translational Medicine
#171
of 4,645 outputs
Outputs of similar age
#3,300
of 130,315 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 30 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,645 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,315 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.