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Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome

Overview of attention for article published in Critical Care, May 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 news outlet
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7 X users

Citations

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26 Dimensions

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39 Mendeley
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Title
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome
Published in
Critical Care, May 2016
DOI 10.1186/s13054-016-1330-5
Pubmed ID
Authors

Anil Sapru, Kathleen D. Liu, Joseph Wiemels, Helen Hansen, Ludmilla Pawlikowska, Annie Poon, Eric Jorgenson, John S. Witte, Carolyn S. Calfee, Lorraine B. Ware, Michael A. Matthay, the NHLBI ARDS Network

Abstract

Altered plasma levels of protein C, thrombomodulin, and the endothelial protein C receptor are associated with poor clinical outcomes in patients with acute respiratory distress syndrome (ARDS). We hypothesized that common variants in these genes would be associated with mortality as well as ventilator-free and organ failure-free days in patients with ARDS. We genotyped linkage disequilibrium-based tag single-nucleotide polymorphisms in the ProteinC, Thrombomodulin and Endothelial Protein C Reptor Genes among 320 self-identified white patients of European ancestry from the ARDS Network Fluid and Catheter Treatment Trial. We then tested their association with mortality as well as ventilator-free and organ-failure free days. The GG genotype of rs1042580 (p = 0.02) and CC genotype of rs3716123 (p = 0.002), both in the thrombomodulin gene, and GC/CC genotypes of rs9574 (p = 0.04) in the endothelial protein C receptor gene were independently associated with increased mortality. An additive effect on mortality (p < 0.001), ventilator-free days (p = 0.01), and organ failure-free days was observed with combinations of these high-risk genotypes. This association was independent of age, severity of illness, presence or absence of sepsis, and treatment allocation. Genetic variants in thrombomodulin and endothelial protein C receptor genes are additively associated with mortality in ARDS. These findings suggest that genetic differences may be at least partially responsible for the observed associations between dysregulated coagulation and poor outcomes in ARDS.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Other 5 13%
Student > Master 4 10%
Student > Ph. D. Student 3 8%
Student > Bachelor 2 5%
Other 7 18%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 17 44%
Biochemistry, Genetics and Molecular Biology 4 10%
Nursing and Health Professions 4 10%
Immunology and Microbiology 2 5%
Computer Science 1 3%
Other 2 5%
Unknown 9 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2016.
All research outputs
#2,745,320
of 25,371,288 outputs
Outputs from Critical Care
#2,368
of 6,554 outputs
Outputs of similar age
#46,277
of 348,582 outputs
Outputs of similar age from Critical Care
#79
of 115 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,582 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.