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X Demographics
Mendeley readers
Attention Score in Context
| Title |
PBDE flame retardants, thyroid disease, and menopausal status in U.S. women
|
|---|---|
| Published in |
Environmental Health, May 2016
|
| DOI | 10.1186/s12940-016-0141-0 |
| Pubmed ID | |
| Authors |
Joseph G. Allen, Sara Gale, R. Thomas Zoeller, John D. Spengler, Linda Birnbaum, Eileen McNeely |
| Abstract |
Women have elevated rates of thyroid disease compared to men. Environmental toxicants have been implicated as contributors to this dimorphism, including polybrominated diphenyl ethers (PBDEs), flame retardant chemicals that disrupt thyroid hormone action. PBDEs have also been implicated in the disruption of estrogenic activity, and estrogen levels regulate thyroid hormones. Post-menopausal women may therefore be particularly vulnerable to PBDE induced thyroid effects, given low estrogen reserves. The objective of this study was to test for an association between serum PBDE concentrations and thyroid disease in women from the United States (U.S.), stratified by menopause status. Serum PBDE concentrations (BDEs 47, 99, 100 and 153) from the National Health and Examination Survey (NHANES) and reports on thyroid problems were available in the NHANES 2003-2004 cycle. Odds ratios (ORs) were calculated using multivariate logistic regression models accounting for population-weighted survey techniques and controlling for age, body mass index (BMI), education, smoking, alcohol consumption and thyroid medication. Menopause status was obtained by self-reported absence of menstruation in the previous 12 months and declared menopause. Women in the highest quartile of serum concentrations for BDEs 47, 99, and 100 had increased odds of currently having thyroid disease (ORs: 1.5, 1.8, 1.5, respectively) compared to the reference group (1st and 2nd quartiles combined); stronger associations were observed when the analysis was restricted to postmenopausal women (ORs: 2.2, 3.6, 2.0, respectively). Exposure to BDEs 47, 99, and 100 is associated with thyroid disease in a national sample of U.S. women, with greater effects observed post-menopause, suggesting that the disruption of thyroid signaling by PBDEs may be enhanced by the altered estrogen levels during menopause. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 52% |
| Germany | 2 | 10% |
| Switzerland | 2 | 10% |
| United Kingdom | 1 | 5% |
| Mexico | 1 | 5% |
| Unknown | 4 | 19% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 71% |
| Practitioners (doctors, other healthcare professionals) | 3 | 14% |
| Scientists | 3 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 95 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Student > Ph. D. Student | 15 | 15% |
| Student > Master | 11 | 11% |
| Researcher | 8 | 8% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 28 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 18 | 19% |
| Medicine and Dentistry | 11 | 11% |
| Chemistry | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 33 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 674. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2019.
All research outputs
#31,601
of 25,519,924 outputs
Outputs from Environmental Health
#17
of 1,606 outputs
Outputs of similar age
#599
of 349,038 outputs
Outputs of similar age from Environmental Health
#2
of 24 outputs
Altmetric has tracked 25,519,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,606 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,038 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.