Title |
Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease
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Published in |
Gut Pathogens, June 2012
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DOI | 10.1186/1757-4749-4-6 |
Pubmed ID | |
Authors |
Natalia Elguezabal, Susana Chamorro, Elena Molina, Joseba M Garrido, Ander Izeta, Luis Rodrigo, Ramón A Juste |
Abstract |
Inflammatory Bowel Disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), is caused by a complex interplay involving genetic predisposition, environmental factors and an infectious agent. Mycobacterium avium subsp. paratuberculosis (MAP) is a promising pathogen candidate since it produces a chronic intestinal inflammatory disease in ruminants that resembles CD in humans. MAP is a ubiquitous microorganism, although its presence in the food chain, especially in milk from infected animals, is what made us think that there could be an association between lactase persistence (LP) and IBD. The LCT mutation has brought adaptation to dairy farming which in turn would have increased exposure of the population to infection by MAP. NOD2 gene mutations are highly associated to CD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Unknown | 44 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 33% |
Student > Ph. D. Student | 9 | 20% |
Student > Doctoral Student | 5 | 11% |
Other | 3 | 7% |
Student > Master | 2 | 4% |
Other | 5 | 11% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 35% |
Veterinary Science and Veterinary Medicine | 5 | 11% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 9% |
Unknown | 10 | 22% |