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The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Overview of attention for article published in Journal of Neuroinflammation, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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1 blog
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4 X users
facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

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162 Dimensions

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mendeley
228 Mendeley
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Title
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
Published in
Journal of Neuroinflammation, July 2012
DOI 10.1186/1742-2094-9-153
Pubmed ID
Authors

Raymond H Thomas, Melissa M Meeking, Jennifer R Mepham, Lisa Tichenoff, Fred Possmayer, Suya Liu, Derrick F MacFabe

Abstract

Gastrointestinal symptoms and altered blood phospholipid profiles have been reported in patients with autism spectrum disorders (ASD). Most of the phospholipid analyses have been conducted on the fatty acid composition of isolated phospholipid classes following hydrolysis. A paucity of information exists on how the intact phospholipid molecular species are altered in ASD. We applied ESI/MS to determine how brain and blood intact phospholipid species were altered during the induction of ASD-like behaviors in rats following intraventricular infusions with the enteric bacterial metabolite propionic acid. Animals were infused daily for 8 days, locomotor activity assessed, and animals killed during the induced behaviors. Propionic acid infusions increased locomotor activity. Lipid analysis revealed treatment altered 21 brain and 30 blood phospholipid molecular species. Notable alterations were observed in the composition of brain SM, diacyl mono and polyunsaturated PC, PI, PS, PE, and plasmalogen PC and PE molecular species. These alterations suggest that the propionic acid rat model is a useful tool to study aberrations in lipid metabolism known to affect membrane fluidity, peroxisomal function, gap junction coupling capacity, signaling, and neuroinflammation, all of which may be associated with the pathogenesis of ASD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Germany 1 <1%
Korea, Republic of 1 <1%
Australia 1 <1%
Ireland 1 <1%
Japan 1 <1%
India 1 <1%
Unknown 220 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 16%
Student > Master 36 16%
Student > Bachelor 35 15%
Researcher 20 9%
Student > Doctoral Student 13 6%
Other 39 17%
Unknown 49 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 19%
Medicine and Dentistry 27 12%
Biochemistry, Genetics and Molecular Biology 23 10%
Neuroscience 18 8%
Pharmacology, Toxicology and Pharmaceutical Science 9 4%
Other 50 22%
Unknown 57 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2021.
All research outputs
#2,302,933
of 22,669,724 outputs
Outputs from Journal of Neuroinflammation
#323
of 2,605 outputs
Outputs of similar age
#15,430
of 164,217 outputs
Outputs of similar age from Journal of Neuroinflammation
#7
of 62 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.