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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sirtuin functions and modulation: from chemistry to the clinic
|
|---|---|
| Published in |
Clinical Epigenetics, May 2016
|
| DOI | 10.1186/s13148-016-0224-3 |
| Pubmed ID | |
| Authors |
Vincenzo Carafa, Dante Rotili, Mariantonietta Forgione, Francesca Cuomo, Enrica Serretiello, Gebremedhin Solomon Hailu, Elina Jarho, Maija Lahtela-Kakkonen, Antonello Mai, Lucia Altucci |
| Abstract |
Sirtuins are NAD(+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| France | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 348 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| Indonesia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 343 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 14% |
| Researcher | 44 | 13% |
| Student > Bachelor | 44 | 13% |
| Student > Master | 42 | 12% |
| Student > Doctoral Student | 18 | 5% |
| Other | 45 | 13% |
| Unknown | 107 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 78 | 22% |
| Medicine and Dentistry | 41 | 12% |
| Agricultural and Biological Sciences | 40 | 11% |
| Chemistry | 25 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 5% |
| Other | 33 | 9% |
| Unknown | 112 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#5,131,875
of 25,321,938 outputs
Outputs from Clinical Epigenetics
#371
of 1,430 outputs
Outputs of similar age
#81,505
of 343,959 outputs
Outputs of similar age from Clinical Epigenetics
#14
of 29 outputs
Altmetric has tracked 25,321,938 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,430 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,959 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.