@fitterhappierAJ @NickytaLeb @valnevaSE @Unusual_Times @PeacockFlu “M1 classically activated macrophages with accelerated formation of viral reservoirs in a context of Th1 and proinflammatory cytokines. Then IL-4/IL-13 alternatively activated M2 macrophage
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“Since the capacity of macrophages to support productive HIV-1 infection is known to be modulated by cytokines, this review shows how modulation of macrophage activation by cytokines impacts the capacity to support productive HIV-1 infection.” https://t.co
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7/10: HIV comes into play In chronic HIV, macrophage activation pathway actually switches from Th1 (IFN-gamma) mediated to Th2 (IL4/13) medaited, called the alternate pathway. This leads to a greater diversity in T cells. https://t.co/QGBjwM5LdG