Title |
Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children
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Published in |
Molecular Autism, July 2012
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DOI | 10.1186/2040-2392-3-6 |
Pubmed ID | |
Authors |
Teresa Tavassoli, Bonnie Auyeung, Laura C Murphy, Simon Baron-Cohen, Bhismadev Chakrabarti |
Abstract |
Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions. In mice, heterozygous Gabrb3 deletion is associated with increased tactile sensitivity. However, no study has examined if tactile sensitivity is associated with GABRB3 genetic variation in humans. To test this, we conducted two pilot genetic association studies in the general population, analysing two phenotypic measures of tactile sensitivity (a parent-report and a behavioural measure) for association with 43 SNPs in GABRB3. |
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United Kingdom | 3 | 43% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 43% |
Members of the public | 3 | 43% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 3% |
Unknown | 74 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 22% |
Researcher | 14 | 18% |
Student > Master | 12 | 16% |
Student > Postgraduate | 7 | 9% |
Student > Bachelor | 7 | 9% |
Other | 10 | 13% |
Unknown | 9 | 12% |
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Agricultural and Biological Sciences | 11 | 14% |
Medicine and Dentistry | 10 | 13% |
Neuroscience | 9 | 12% |
Social Sciences | 3 | 4% |
Other | 7 | 9% |
Unknown | 14 | 18% |