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Re-emergence of the susceptibility of the Salmonella spp. isolated from blood samples to conventional first line antibiotics

Overview of attention for article published in Antimicrobial Resistance and Infection Control, May 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

Mentioned by

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4 tweeters

Citations

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23 Dimensions

Readers on

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47 Mendeley
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Title
Re-emergence of the susceptibility of the Salmonella spp. isolated from blood samples to conventional first line antibiotics
Published in
Antimicrobial Resistance and Infection Control, May 2016
DOI 10.1186/s13756-016-0121-8
Pubmed ID
Authors

Krishma Laxmi Shrestha, Narayan Dutt Pant, Raju Bhandari, Sabita Khatri, Basudha Shrestha, Binod Lekhak, Shrestha, Krishma Laxmi, Pant, Narayan Dutt, Bhandari, Raju, Khatri, Sabita, Shrestha, Basudha, Lekhak, Binod

Abstract

Enteric fever is an important public health problem in Nepal. Due to emergence of multidrug resistant strains of Salmonella spp. the conventional first-line drugs, ampicillin, chloramphenicol, and cotrimoxazole have not been used as empiric therapy for treatment of enteric fever for last two decades and there have been increased uses of fluoroquinolones as the drugs of choice. The aim of this study was to evaluate and analyze the antimicrobial susceptibility patterns of Salmonella spp. A total of 620 blood samples collected from the patients suspected of suffering from enteric fever were cultured using standard microbiological techniques. Antibiotic susceptibility testing of the Salmonella spp., was performed by Kirby Bauer disc diffusion technique following Clinical and Laboratory Standard Institute (CLSI) guidelines. Minimum inhibitory concentrations of ciprofloxacin, ofloxacin and nalidixic acid were determined by agar dilution method. Of the total 83 Salmonella spp., 48 (57.83 %) were S. Typhi and 35 (42.26 %) were S. Paratyphi A. Among 83 Salmonella isolates, 98.8 % of the Salmonella spp. were susceptible to chloramphenicol and co-trimoxazole and about 97.6 % of the isolates were susceptible to ampicillin. Similarly, 69 (83.13 %) isolates were resistant to nalidixic acid. Only 16.9 % of the isolates were susceptible to ciprofloxacin. One S. Typhi isolate was multidrug resistant. The present study revealed the decreased susceptibility of the S. Typhi and S. Paratyphi A to fluoroquinolones, proving them to be inappropriate for empirical therapy for the treatment of enteric fever in our setting. Further the higher susceptibility of the isolates to first line drugs, ampicillin, chloramphenicol, and cotrimoxazole suggests the possibility of using these drugs for empirical therapy.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 21%
Researcher 9 19%
Student > Postgraduate 5 11%
Student > Bachelor 5 11%
Student > Ph. D. Student 5 11%
Other 7 15%
Unknown 6 13%
Readers by discipline Count As %
Medicine and Dentistry 10 21%
Immunology and Microbiology 10 21%
Biochemistry, Genetics and Molecular Biology 5 11%
Agricultural and Biological Sciences 5 11%
Veterinary Science and Veterinary Medicine 2 4%
Other 8 17%
Unknown 7 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2016.
All research outputs
#3,449,497
of 7,847,043 outputs
Outputs from Antimicrobial Resistance and Infection Control
#202
of 289 outputs
Outputs of similar age
#111,994
of 269,204 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#12
of 15 outputs
Altmetric has tracked 7,847,043 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 289 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,204 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.