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Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Overview of attention for article published in Journal of Neuroinflammation, March 2012
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Title
Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system
Published in
Journal of Neuroinflammation, March 2012
DOI 10.1186/1742-2094-9-61
Pubmed ID
Authors

Astrid Bottelbergs, Simon Verheijden, Paul P Van Veldhoven, Wilhelm Just, Rita Devos, Myriam Baes

Abstract

Mice with peroxisome deficiency in neural cells (Nestin-Pex5-/-) develop a neurodegenerative phenotype leading to motor and cognitive disabilities and early death. Major pathologies at the end stage of disease include severe demyelination, axonal degeneration and neuroinflammation. We now investigated the onset and progression of these pathological processes, and their potential interrelationship. In addition, the putative role of oxidative stress, the impact of plasmalogen depletion on the neurodegenerative phenotype, and the consequences of peroxisome elimination in the postnatal period were studied.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 3%
Germany 1 1%
Unknown 70 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 22%
Researcher 14 19%
Student > Bachelor 9 12%
Student > Master 7 10%
Professor > Associate Professor 5 7%
Other 12 16%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 26%
Biochemistry, Genetics and Molecular Biology 15 21%
Neuroscience 11 15%
Medicine and Dentistry 6 8%
Nursing and Health Professions 2 3%
Other 6 8%
Unknown 14 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2012.
All research outputs
#20,160,460
of 22,669,724 outputs
Outputs from Journal of Neuroinflammation
#2,284
of 2,605 outputs
Outputs of similar age
#145,287
of 160,422 outputs
Outputs of similar age from Journal of Neuroinflammation
#32
of 37 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,422 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.