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Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge

Overview of attention for article published in Veterinary Research, July 2012
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Title
Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge
Published in
Veterinary Research, July 2012
DOI 10.1186/1297-9716-43-56
Pubmed ID
22770566
Authors

Xia Yu, Renyong Jia, Juan Huang, Bin Shu, Dekang Zhu, Qing Liu, Xinghong Gao, Meng Lin, Zhongqiong Yin, Mingshu Wang, Shun Chen, Yin Wang, Xiaoyue Chen, Anchun Cheng

Abstract

Orally delivered DNA vaccines against duck enteritis virus (DEV) were developed using live attenuated Salmonella typhimurium (SL7207) as a carrier and Escherichia coli heat labile enterotoxin B subunit (LTB) as a mucosal adjuvant. DNA vaccine plasmids pVAX-UL24 and pVAX-LTB-UL24 were constructed and transformed into attenuated Salmonella typhimurium SL7207 resulting SL7207 (pVAX-UL24) and SL7207 (pVAX-LTB-UL24) respectively. After ducklings were orally inoculated with SL7207 (pVAX-UL24) or SL7207 (pVAX-LTB-UL24), the anti-DEV mucosal and systemic immune responses were recorded. To identify the optimum dose that confers maximum protection, we used different doses of the candidate vaccine SL7207 (pVAX-LTB-UL24) during oral immunization. The strongest mucosal and systemic immune responses developed in the SL7207 (pVAX-LTB-UL24) (1011 CFU) immunized group. Accordingly, oral immunization of ducklings with SL7207 (pVAX-LTB-UL24) showed superior efficacy of protection (60-80%) against a lethal DEV challenge (1000 LD50), compared with the limited survival rate (40%) of ducklings immunized with SL7207 (pVAX-UL24). Our study suggests that the SL7207 (pVAX-LTB-UL24) can be a candidate DEV vaccine.

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 15%
Student > Bachelor 4 15%
Student > Postgraduate 4 15%
Researcher 3 12%
Professor > Associate Professor 2 8%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 19%
Immunology and Microbiology 4 15%
Veterinary Science and Veterinary Medicine 2 8%
Agricultural and Biological Sciences 2 8%
Medicine and Dentistry 2 8%
Other 4 15%
Unknown 7 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2012.
All research outputs
#20,160,460
of 22,669,724 outputs
Outputs from Veterinary Research
#1,044
of 1,193 outputs
Outputs of similar age
#148,004
of 164,297 outputs
Outputs of similar age from Veterinary Research
#4
of 4 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,297 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.

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