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A case of multicentric gliomas in both supra- and infratentorial regions with different histology: a case report

Overview of attention for article published in World Journal of Surgical Oncology, January 2016
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Title
A case of multicentric gliomas in both supra- and infratentorial regions with different histology: a case report
Published in
World Journal of Surgical Oncology, January 2016
DOI 10.1186/s12957-016-0907-4
Pubmed ID
Authors

Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Yosuke Mizuno, Riko Kitazawa, Yawara Nakamura, Shiro Ohue, Inoue, Akihiro, Ohnishi, Takanori, Kohno, Shohei, Mizuno, Yosuke, Kitazawa, Riko, Nakamura, Yawara, Ohue, Shiro

Abstract

Multicentric gliomas are well-separated tumors in different locations of the brain, without anatomical continuity between lesions. We report a rare case of multicentric gliomas that occurred in both supra- and infratentorial regions with different histopathology. A 27-year-old man was admitted to our hospital with mild motor weakness of the right leg. Magnetic resonance imaging (MRI) showed a large tumor occupying the left insula, extending to the left basal ganglia, so tumor resection was performed. Histological diagnosis was diffuse astrocytoma. Tumor cells showed sporadic immunoreactivity for p53 and negative immunostaining for epidermal growth factor receptor (EGFR). Postoperative course was uneventful, and adjuvant therapy was not performed. At 7 months after surgery, MRI disclosed a left cerebellar tumor displaying an irregular ring formation on enhancement with gadolinium (Gd) and marked peritumoral edema. MRI studies including T2-weighted imaging demonstrated that this paravermian tumor had no contact with the initial left insular tumor. In addition, MRI studies of the whole neuraxis, cytological examination of the cerebrospinal fluid, and neurological findings demonstrated that no dissemination had occurred through the subarachnoid space or as intracerebral metastases. Therefore, the second surgery was performed. Histological diagnosis was glioblastoma. Immunohistochemistry revealed that most tumor cells were positively stained for both p53 and EGFR but negatively stained for isocitrate dehydrogenase 1 (IDH1). We reported a case of multicentric gliomas occurring in both supra- and infratentorial regions with different histopathology. Immunohistochemical examinations suggest that different genetic pathways may participate in the occurrence of these tumors.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 25%
Other 5 14%
Student > Master 4 11%
Student > Ph. D. Student 4 11%
Student > Postgraduate 3 8%
Other 7 19%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 20 56%
Neuroscience 3 8%
Nursing and Health Professions 2 6%
Arts and Humanities 1 3%
Physics and Astronomy 1 3%
Other 1 3%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
All research outputs
#14,623,847
of 16,578,610 outputs
Outputs from World Journal of Surgical Oncology
#1,311
of 1,557 outputs
Outputs of similar age
#223,410
of 269,811 outputs
Outputs of similar age from World Journal of Surgical Oncology
#5
of 15 outputs
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.