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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
|
|---|---|
| Published in |
Malaria Journal, May 2016
|
| DOI | 10.1186/s12936-016-1342-2 |
| Pubmed ID | |
| Authors |
Caroline Pehrson, Line Mathiesen, Kristine K. Heno, Ali Salanti, Mafalda Resende, Ron Dzikowski, Peter Damm, Stefan R. Hansson, Christopher L. King, Henning Schneider, Christian W. Wang, Thomas Lavstsen, Thor G. Theander, Lisbeth E. Knudsen, Morten A. Nielsen |
| Abstract |
Placental malaria occurs when Plasmodium falciparum infected erythrocytes sequester in the placenta. Placental parasite isolates bind to chondroitin sulphate A (CSA) by expression of VAR2CSA on the surface of infected erythrocytes, but may sequester by other VAR2CSA mediated mechanisms, such as binding to immunoglobulins. Furthermore, other parasite antigens have been associated with placental malaria. These findings have important implications for placental malaria vaccine design. The objective of this study was to adapt and describe a biologically relevant model of parasite adhesion in intact placental tissue. The ex vivo placental perfusion model was modified to study adhesion of infected erythrocytes binding to CSA, endothelial protein C receptor (EPCR) or a transgenic parasite where P. falciparum erythrocyte membrane protein 1 expression had been shut down. Infected erythrocytes expressing VAR2CSA accumulated in perfused placental tissue whereas the EPCR binding and the transgenic parasite did not. Soluble CSA and antibodies specific against VAR2CSA inhibited binding of infected erythrocytes. The ex vivo model provides a novel way of studying receptor-ligand interactions and antibody mediated inhibition of binding in placental malaria. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 88 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Student > Bachelor | 15 | 17% |
| Researcher | 9 | 10% |
| Student > Master | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 12 | 13% |
| Unknown | 22 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 13 | 15% |
| Medicine and Dentistry | 11 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Agricultural and Biological Sciences | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
| Other | 12 | 13% |
| Unknown | 25 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
All research outputs
#15,376,252
of 22,875,477 outputs
Outputs from Malaria Journal
#4,489
of 5,579 outputs
Outputs of similar age
#210,145
of 337,040 outputs
Outputs of similar age from Malaria Journal
#125
of 156 outputs
Altmetric has tracked 22,875,477 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,579 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.