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Nociceptive transmission and modulation via P2X receptors in central pain syndrome

Overview of attention for article published in Molecular Brain, May 2016
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

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Title
Nociceptive transmission and modulation via P2X receptors in central pain syndrome
Published in
Molecular Brain, May 2016
DOI 10.1186/s13041-016-0240-4
Pubmed ID
Authors

Yung-Hui Kuan, Bai-Chuang Shyu

Abstract

Painful sensations are some of the most frequent complaints of patients who are admitted to local medical clinics. Persistent pain varies according to its causes, often resulting from local tissue damage or inflammation. Central somatosensory pathway lesions that are not adequately relieved can consequently cause central pain syndrome or central neuropathic pain. Research on the molecular mechanisms that underlie this pathogenesis is important for treating such pain. To date, evidence suggests the involvement of ion channels, including adenosine triphosphate (ATP)-gated cation channel P2X receptors, in central nervous system pain transmission and persistent modulation upon and following the occurrence of neuropathic pain. Several P2X receptor subtypes, including P2X2, P2X3, P2X4, and P2X7, have been shown to play diverse roles in the pathogenesis of central pain including the mediation of fast transmission in the peripheral nervous system and modulation of neuronal activity in the central nervous system. This review article highlights the role of the P2X family of ATP receptors in the pathogenesis of central neuropathic pain and pain transmission. We discuss basic research that may be translated to clinical application, suggesting that P2X receptors may be treatment targets for central pain syndrome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 18%
Student > Bachelor 8 12%
Student > Master 8 12%
Researcher 7 11%
Other 6 9%
Other 9 14%
Unknown 15 23%
Readers by discipline Count As %
Neuroscience 11 17%
Medicine and Dentistry 9 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 11%
Biochemistry, Genetics and Molecular Biology 6 9%
Agricultural and Biological Sciences 5 8%
Other 11 17%
Unknown 16 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2020.
All research outputs
#12,763,849
of 22,875,477 outputs
Outputs from Molecular Brain
#387
of 1,111 outputs
Outputs of similar age
#162,176
of 337,040 outputs
Outputs of similar age from Molecular Brain
#9
of 31 outputs
Altmetric has tracked 22,875,477 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,111 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.