Title |
Glycine confers neuroprotection through microRNA-301a/PTEN signaling
|
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Published in |
Molecular Brain, May 2016
|
DOI | 10.1186/s13041-016-0241-3 |
Pubmed ID | |
Authors |
Juan Chen, Yang Zhuang, Zhi-Feng Zhang, Shu Wang, Ping Jin, Chunjiang He, Peng-Chao Hu, Ze-Fen Wang, Zhi-Qiang Li, Guang-Ming Xia, Gang Li, Yuan Wang, Qi Wan |
Abstract |
Glycine is known to protect against neuronal death. However, the underlying mechanism remains to be elucidated. The microRNA-301a is involved in both biological and pathological processes. But it is not known whether microRNA-301a has a neuroprotective property. In this study, we aimed to determine whether glycine-induced neuroprotection requires microRNA-301a-dependent signaling. We provided the first evidence that glycine increased the expression of microRNA-301a in cultured rat cortical neurons and protected against cortical neuronal death through up-regulation of microRNA-301a after oxygen-glucose deprivation. MicroRNA-301a directly bound the predicted 3'UTR target sites of PTEN and reduced PTEN expression in cortical neurons. We revealed that PTEN down-regulation by microRNA-301a mediated glycine-induced neuroprotective effect following oxygen-glucose deprivation. Our results suggest that 1) microRNA-301a is neuroprotective in oxygen-glucose deprivation-induced neuronal injury; 2) glycine is an upstream regulator of microRNA-301a; 3) glycine confers neuroprotection through microRNA-301a/PTEN signal pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Saudi Arabia | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 24% |
Student > Ph. D. Student | 4 | 24% |
Professor > Associate Professor | 2 | 12% |
Other | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Neuroscience | 3 | 18% |
Medicine and Dentistry | 3 | 18% |
Immunology and Microbiology | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 29% |