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Augmenter of liver regeneration

Overview of attention for article published in Fibrogenesis & Tissue Repair, July 2012
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1 tweeter

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46 Dimensions

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47 Mendeley
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Title
Augmenter of liver regeneration
Published in
Fibrogenesis & Tissue Repair, July 2012
DOI 10.1186/1755-1536-5-10
Pubmed ID
Authors

Chandrashekhar R Gandhi

Abstract

'Augmenter of liver regeneration' (ALR) (also known as hepatic stimulatory substance or hepatopoietin) was originally found to promote growth of hepatocytes in the regenerating or injured liver. ALR is expressed ubiquitously in all organs, and exclusively in hepatocytes in the liver. ALR, a survival factor for hepatocytes, exhibits significant homology with ERV1 (essential for respiration and viability) protein that is essential for the survival of the yeast, Saccharomyces cerevisiae. ALR comprises 198 to 205 amino acids (approximately 22 kDa), but is post-translationally modified to three high molecular weight species (approximately 38 to 42 kDa) found in hepatocytes. ALR is present in mitochondria, cytosol, endoplasmic reticulum, and nucleus. Mitochondrial ALR may be involved in oxidative phosphorylation, but also functions as sulfhydryl oxidase and cytochrome c reductase, and causes Fe/S maturation of proteins. ALR, secreted by hepatocytes, stimulates synthesis of TNF-α, IL-6, and nitric oxide in Kupffer cells via a G-protein coupled receptor. While the 22 kDa rat recombinant ALR does not stimulate DNA synthesis in hepatocytes, the short form (15 kDa) of human recombinant ALR was reported to be equipotent as or even stronger than TGF-α or HGF as a mitogen for hepatocytes. Altered serum ALR levels in certain pathological conditions suggest that it may be a diagnostic marker for liver injury/disease. Although ALR appears to have multiple functions, the knowledge of its role in various organs, including the liver, is extremely inadequate, and it is not known whether different ALR species have distinct functions. Future research should provide better understanding of the expression and functions of this enigmatic molecule.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Germany 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 28%
Student > Master 6 13%
Student > Bachelor 5 11%
Researcher 4 9%
Professor > Associate Professor 3 6%
Other 8 17%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 28%
Medicine and Dentistry 8 17%
Chemistry 6 13%
Biochemistry, Genetics and Molecular Biology 6 13%
Neuroscience 2 4%
Other 4 9%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2012.
All research outputs
#7,807,566
of 12,445,334 outputs
Outputs from Fibrogenesis & Tissue Repair
#47
of 67 outputs
Outputs of similar age
#66,830
of 119,666 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#4
of 6 outputs
Altmetric has tracked 12,445,334 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 67 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,666 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.