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Sublingual nucleotides and immune response to exercise

Overview of attention for article published in Journal of the International Society of Sports Nutrition, April 2022
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Title
Sublingual nucleotides and immune response to exercise
Published in
Journal of the International Society of Sports Nutrition, April 2022
DOI 10.1186/1550-2783-9-31
Pubmed ID
Authors

Sergej M Ostojic, Milos Obrenovic

Abstract

Evidence exists regarding the potential role of exogenous nucleotides as regulators of the immune function in physically active humans, yet the potential use of nucleotides has been hindered by their low bioavailability after oral administration. We conducted a double-blind, placebo-controlled, randomized trial to assess the effect of sublingual nucleotides (50 mg/day) on salivary and serum immunity indicators as compared to placebo, both administered to healthy males aged 20 to 25 years for 14 days. Sublingual administration of nucleotides for 14 days increased serum immunoglobulin A, natural killer cells count and cytotoxic activity, and offset the post-exercise drop of salivary immunoglobulins and lactoferrin (P < 0.05), with no adverse effects reported. No significant differences in fasting salivary antimicrobal proteins (α-amylase, lysozyme and lactoferrin) were found before or after the treatment (P > 0.05). It seems that sublingual administration of nucleotides for two weeks considerably affected immune function in healthy males.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Portugal 1 2%
France 1 2%
Canada 1 2%
Unknown 38 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 21%
Researcher 6 14%
Student > Ph. D. Student 5 12%
Professor > Associate Professor 4 10%
Student > Master 4 10%
Other 8 19%
Unknown 6 14%
Readers by discipline Count As %
Sports and Recreations 9 21%
Medicine and Dentistry 7 17%
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 2 5%
Other 7 17%
Unknown 8 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2012.
All research outputs
#18,310,549
of 22,671,366 outputs
Outputs from Journal of the International Society of Sports Nutrition
#816
of 882 outputs
Outputs of similar age
#315,399
of 437,591 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#785
of 849 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 882 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.4. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 437,591 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 849 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.