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The Philadelphia chromosome in leukemogenesis

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#14 of 223)
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

news
1 news outlet
wikipedia
1 Wikipedia page

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
334 Mendeley
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Title
The Philadelphia chromosome in leukemogenesis
Published in
Ai zheng Aizheng Chinese journal of cancer, May 2016
DOI 10.1186/s40880-016-0108-0
Pubmed ID
Authors

Zhi-Jie Kang, Yu-Fei Liu, Ling-Zhi Xu, Zi-Jie Long, Dan Huang, Ya Yang, Bing Liu, Jiu-Xing Feng, Yu-Jia Pan, Jin-Song Yan, Quentin Liu

Abstract

The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability. This aberrant fusion gene encodes the breakpoint cluster region-proto-oncogene tyrosine-protein kinase (BCR-ABL1) oncogenic protein with persistently enhanced tyrosine kinase activity. The kinase activity is responsible for maintaining proliferation, inhibiting differentiation, and conferring resistance to cell death. During the progression of CML from the chronic phase to the accelerated phase and then to the blast phase, the expression patterns of different BCR-ABL1 transcripts vary. Each BCR-ABL1 transcript is present in a distinct leukemia phenotype, which predicts both response to therapy and clinical outcome. Besides CML, the Ph is found in acute lymphoblastic leukemia, acute myeloid leukemia, and mixed-phenotype acute leukemia. Here, we provide an overview of the clinical presentation and cellular biology of different phenotypes of Ph-positive leukemia and highlight key findings regarding leukemogenesis.

Mendeley readers

The data shown below were compiled from readership statistics for 334 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 <1%
Kenya 1 <1%
Unknown 331 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 95 28%
Student > Master 58 17%
Student > Ph. D. Student 47 14%
Student > Doctoral Student 16 5%
Student > Postgraduate 16 5%
Other 33 10%
Unknown 69 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 102 31%
Medicine and Dentistry 61 18%
Agricultural and Biological Sciences 36 11%
Immunology and Microbiology 16 5%
Pharmacology, Toxicology and Pharmaceutical Science 16 5%
Other 30 9%
Unknown 73 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2020.
All research outputs
#2,063,646
of 16,699,900 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#14
of 223 outputs
Outputs of similar age
#42,544
of 269,977 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#1
of 1 outputs
Altmetric has tracked 16,699,900 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them