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Genetics of migraine in the age of genome-wide association studies

Overview of attention for article published in Journal of Headache & Pain, November 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
wikipedia
16 Wikipedia pages

Citations

dimensions_citation
72 Dimensions

Readers on

mendeley
105 Mendeley
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Title
Genetics of migraine in the age of genome-wide association studies
Published in
Journal of Headache & Pain, November 2011
DOI 10.1007/s10194-011-0399-0
Pubmed ID
Authors

Markus Schürks

Abstract

Genetic factors importantly contribute to migraine. However, unlike for rare monogenic forms of migraine, approaches to identify genes for common forms of migraine have been of limited success. Candidate gene association studies were often negative and positive results were often not replicated or replication failed. Further, the significance of positive results from linkage studies remains unclear owing to the inability to pinpoint the genes under the peaks that may be involved in migraine. Problems hampering these studies include limited sample sizes, methods of migraine ascertainment, and the heterogeneous clinical phenotype. Three genome-wide association studies are available now and have successfully identified four new genetic variants associated with migraine. One new variant (rs1835740) modulates glutamate homeostasis, thus integrates well with current concepts of neurotransmitter disturbances. This variant may be more specific for severe forms of migraine such as migraine with aura than migraine without aura. Another variant (rs11172113) implicates the lipoprotein receptor LRP1, which may interact with neuronal glutamate receptors, thus also providing a link to the glutamate pathway. In contrast, rs10166942 is in close proximity to TRPM8, which codes for a cold and pain sensor. For the first time this links a gene explicitly implicated in pain related pathways to migraine. The potential function of the fourth variant rs2651899 (PRDM16) in migraine is unclear. All these variants only confer a small to moderate change in risk for migraine, which concurs with migraine being a heterogeneous disorder. Ongoing large international collaborations will likely identify additional gene variants for migraine.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
India 1 <1%
Denmark 1 <1%
Unknown 102 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 20%
Student > Master 19 18%
Student > Bachelor 16 15%
Researcher 13 12%
Student > Doctoral Student 9 9%
Other 18 17%
Unknown 9 9%
Readers by discipline Count As %
Medicine and Dentistry 37 35%
Agricultural and Biological Sciences 20 19%
Biochemistry, Genetics and Molecular Biology 9 9%
Neuroscience 8 8%
Psychology 4 4%
Other 14 13%
Unknown 13 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2020.
All research outputs
#1,881,721
of 17,175,498 outputs
Outputs from Journal of Headache & Pain
#198
of 1,057 outputs
Outputs of similar age
#13,715
of 133,116 outputs
Outputs of similar age from Journal of Headache & Pain
#1
of 12 outputs
Altmetric has tracked 17,175,498 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,057 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,116 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.