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JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain

Overview of attention for article published in Journal of Neuroinflammation, July 2012
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1 Facebook page

Citations

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72 Mendeley
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Title
JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain
Published in
Journal of Neuroinflammation, July 2012
DOI 10.1186/1742-2094-9-175
Pubmed ID
Authors

Lan-Wan Wang, Yi-Fang Tu, Chao-Ching Huang, Chien-Jung Ho

Abstract

White matter injury is the major form of brain damage in very preterm infants. Selective white matter injury in the immature brain can be induced by lipopolysaccharide (LPS)-sensitized hypoxic-ischemia (HI) in the postpartum (P) day 2 rat pups whose brain maturation status is equivalent to that in preterm infants less than 30 weeks of gestation. Neuroinflammation, blood-brain barrier (BBB) damage and oligodendrocyte progenitor apoptosis may affect the susceptibility of LPS-sensitized HI in white matter injury. c-Jun N-terminal kinases (JNK) are important stress-responsive kinases in various forms of insults. We hypothesized that LPS-sensitized HI causes white matter injury through JNK activation-mediated neuroinflammation, BBB leakage and oligodendroglial apoptosis in the white matter of P2 rat pups.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Greece 1 1%
Germany 1 1%
Unknown 68 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 19%
Student > Master 8 11%
Researcher 6 8%
Student > Doctoral Student 6 8%
Student > Bachelor 6 8%
Other 15 21%
Unknown 17 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 21%
Medicine and Dentistry 13 18%
Neuroscience 9 13%
Biochemistry, Genetics and Molecular Biology 7 10%
Psychology 3 4%
Other 6 8%
Unknown 19 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2012.
All research outputs
#16,171,961
of 25,654,806 outputs
Outputs from Journal of Neuroinflammation
#1,821
of 2,969 outputs
Outputs of similar age
#100,546
of 164,341 outputs
Outputs of similar age from Journal of Neuroinflammation
#36
of 60 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,969 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,341 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.