↓ Skip to main content

Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug…

Overview of attention for article published in Retrovirology, July 2012
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal
Published in
Retrovirology, July 2012
DOI 10.1186/1742-4690-9-57
Pubmed ID
Authors

Koen K A Van Rompay, Kristin A Trott, Kartika Jayashankar, Yongzhi Geng, Celia C LaBranche, Jeffrey A Johnson, Gary Landucci, Jonathan Lipscomb, Ross P Tarara, Don R Canfield, Walid Heneine, Donald N Forthal, David Montefiori, Kristina Abel

Abstract

We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus replication for years. Transient CD8+ cell depletion or short-term tenofovir interruption within 1 to 5 years of treatment demonstrated that a combination of CD8+ cell-mediated immune responses and continued tenofovir therapy was required for sustained suppression of viremia. We report here follow-up data on 5 such animals that received tenofovir for 8 to 14 years.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 11%
Unknown 17 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Professor 3 16%
Student > Ph. D. Student 2 11%
Student > Master 2 11%
Student > Bachelor 1 5%
Other 4 21%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 6 32%
Agricultural and Biological Sciences 4 21%
Immunology and Microbiology 3 16%
Unspecified 1 5%
Arts and Humanities 1 5%
Other 2 11%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2012.
All research outputs
#15,247,248
of 22,671,366 outputs
Outputs from Retrovirology
#776
of 1,102 outputs
Outputs of similar age
#91,348
of 143,552 outputs
Outputs of similar age from Retrovirology
#4
of 8 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,102 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,552 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.