Title |
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal
|
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Published in |
Retrovirology, July 2012
|
DOI | 10.1186/1742-4690-9-57 |
Pubmed ID | |
Authors |
Koen K A Van Rompay, Kristin A Trott, Kartika Jayashankar, Yongzhi Geng, Celia C LaBranche, Jeffrey A Johnson, Gary Landucci, Jonathan Lipscomb, Ross P Tarara, Don R Canfield, Walid Heneine, Donald N Forthal, David Montefiori, Kristina Abel |
Abstract |
We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus replication for years. Transient CD8+ cell depletion or short-term tenofovir interruption within 1 to 5 years of treatment demonstrated that a combination of CD8+ cell-mediated immune responses and continued tenofovir therapy was required for sustained suppression of viremia. We report here follow-up data on 5 such animals that received tenofovir for 8 to 14 years. |
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Mendeley readers
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