↓ Skip to main content

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

Overview of attention for article published in Molecular Brain, July 2012
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
5 X users

Citations

dimensions_citation
81 Dimensions

Readers on

mendeley
144 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory
Published in
Molecular Brain, July 2012
DOI 10.1186/1756-6606-5-25
Pubmed ID
Authors

Igor Klyubin, William K Cullen, Neng-Wei Hu, Michael J Rowan

Abstract

Alzheimer's disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic intervention at an early, pre-dementia, stage. Prior to the onset of significant neurodegeneration, the structural and functional integrity of synapses in mnemonic circuitry is severely compromised in the presence of amyloidosis. This review examines recent evidence evaluating the role of amyloid-ß protein (Aβ) in causing rapid disruption of synaptic plasticity and memory impairment. We evaluate the relative importance of different sizes and conformations of Aβ, including monomer, oligomer, protofibril and fibril. We pay particular attention to recent controversies over the relevance to the pathophysiology of AD of different water soluble Aβ aggregates and the importance of cellular prion protein in mediating their effects. Current data are consistent with the view that both low-n oligomers and larger soluble assemblies present in AD brain, some of them via a direct interaction with cellular prion protein, cause synaptic memory failure. At the two extremes of aggregation, monomers and fibrils appear to act in vivo both as sources and sinks of certain metastable conformations of soluble aggregates that powerfully disrupt synaptic plasticity. The same principle appears to apply to other synaptotoxic amyloidogenic proteins including tau, α-synuclein and prion protein.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 1%
United Kingdom 2 1%
India 1 <1%
Mexico 1 <1%
France 1 <1%
Unknown 134 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 24%
Researcher 28 19%
Student > Master 19 13%
Student > Bachelor 11 8%
Professor > Associate Professor 10 7%
Other 23 16%
Unknown 18 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 32%
Neuroscience 18 13%
Biochemistry, Genetics and Molecular Biology 15 10%
Medicine and Dentistry 15 10%
Psychology 10 7%
Other 17 12%
Unknown 23 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2012.
All research outputs
#8,259,085
of 25,374,647 outputs
Outputs from Molecular Brain
#390
of 1,198 outputs
Outputs of similar age
#54,348
of 163,841 outputs
Outputs of similar age from Molecular Brain
#2
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,841 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.