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Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion

Overview of attention for article published in Acta Neuropathologica Communications, June 2016
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Average Attention Score compared to outputs of the same age and source

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4 X users
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1 Facebook page
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1 Google+ user

Citations

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36 Dimensions

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52 Mendeley
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Title
Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion
Published in
Acta Neuropathologica Communications, June 2016
DOI 10.1186/s40478-016-0321-8
Pubmed ID
Authors

John R. Apps, J. Ciaran Hutchinson, Owen J. Arthurs, Alex Virasami, Abhijit Joshi, Berit Zeller-Plumhoff, Dale Moulding, Thomas S. Jacques, Neil J. Sebire, Juan Pedro Martinez-Barbera

Abstract

Tissue invasion and infiltration by brain tumours poses a clinical challenge, with destruction of structures leading to morbidity. We assessed whether micro-CT could be used to map tumour invasion in adamantinomatous craniopharyngioma (ACP), and whether it could delineate ACPs and their intrinsic components from surrounding tissue.Three anonymised archival frozen ACP samples were fixed, iodinated and imaged using a micro-CT scanner prior to the use of standard histological processing and immunohistochemical techniques.We demonstrate that micro-CT imaging can non-destructively give detailed 3D structural information of tumours in volumes with isotropic voxel sizes of 4-6 microns, which can be correlated with traditional histology and immunohistochemistry.Such information complements classical histology by facilitating virtual slicing of the tissue in any plane and providing unique detail of the three dimensional relationships of tissue compartments.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Ph. D. Student 6 12%
Professor 5 10%
Student > Doctoral Student 4 8%
Student > Master 4 8%
Other 10 19%
Unknown 13 25%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Biochemistry, Genetics and Molecular Biology 9 17%
Neuroscience 4 8%
Agricultural and Biological Sciences 3 6%
Computer Science 1 2%
Other 3 6%
Unknown 19 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2017.
All research outputs
#6,299,306
of 22,876,619 outputs
Outputs from Acta Neuropathologica Communications
#905
of 1,379 outputs
Outputs of similar age
#101,250
of 339,345 outputs
Outputs of similar age from Acta Neuropathologica Communications
#18
of 34 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,345 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.