Title |
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition
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Published in |
BMC Cancer, July 2012
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DOI | 10.1186/1471-2407-12-293 |
Pubmed ID | |
Authors |
Sreenivasulu Chintala, Tanbir Najrana, Karoly Toth, Shousong Cao, Farukh A Durrani, Roberto Pili, Youcef M Rustum |
Abstract |
Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of several genes involved in tumor angiogenesis, glycolysis and drug resistance. We have demonstrated inhibition of HIF-1α by Se-Methylselenocysteine (MSC) via stabilization of prolyl hydroxylases 2 and 3 (PHDs) and a significant therapeutic synergy when combined with chemotherapy. This study was initiated to investigate the expression of PHDs, HIF-α, and VEGF-A in selected solid cancers, the mechanism of HIF-α inhibition by MSC, and to document antitumor activity of MSC against human ccRCC xenografts. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Korea, Republic of | 1 | 2% |
United States | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 52 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 16% |
Researcher | 8 | 15% |
Student > Master | 7 | 13% |
Student > Bachelor | 7 | 13% |
Student > Doctoral Student | 3 | 5% |
Other | 12 | 22% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 27% |
Biochemistry, Genetics and Molecular Biology | 13 | 24% |
Agricultural and Biological Sciences | 12 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Unspecified | 1 | 2% |
Other | 3 | 5% |
Unknown | 9 | 16% |