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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Biomimetic microenvironments for regenerative endodontics
|
|---|---|
| Published in |
Biomaterials Research, June 2016
|
| DOI | 10.1186/s40824-016-0061-7 |
| Pubmed ID | |
| Authors |
Sagar N. Kaushik, Bogeun Kim, Alexander M. Cruz Walma, Sung Chul Choi, Hui Wu, Jeremy J. Mao, Ho-Wook Jun, Kyounga Cheon |
| Abstract |
Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem cells, signaling molecules, and scaffolds. In addition, clinical success of the regenerative endodontic treatments can be evidenced by absence of signs and symptoms; no bony pathology, a disinfected pulp, and the maturation of root dentin in length and thickness. In spite of the various approaches of regenerative endodontics, there are several major challenges that remain to be improved: a) the endodontic root canal is a strong harbor of the endodontic bacterial biofilm and the fundamental etiologic factors of recurrent endodontic diseases, (b) tooth discolorations are caused by antibiotics and filling materials, (c) cervical root fractures are caused by endodontic medicaments, (d) pulp tissue is not vascularized nor innervated, and (e) the dentin matrix is not developed with adequate root thickness and length. Generally, current clinical protocols and recent studies have shown a limited success of the pulp-dentin tissue regeneration. Throughout the various approaches, the construction of biomimetic microenvironments of pulp-dentin tissue is a key concept of the tissue engineering based regenerative endodontics. The biomimetic microenvironments are composed of a synthetic nano-scaled polymeric fiber structure that mimics native pulp ECM and functions as a scaffold of the pulp-dentin tissue complex. They will provide a framework of the pulp ECM, can deliver selective bioactive molecules, and may recruit pluripotent stem cells from the vicinity of the pulp apex. The polymeric nanofibers are produced by methods of self-assembly, electrospinning, and phase separation. In order to be applied to biomedical use, the polymeric nanofibers require biocompatibility, stability, and biodegradability. Therefore, this review focuses on the development and application of the biomimetic microenvironments of pulp-dentin tissue among the current regenerative endodontics. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 198 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 31 | 16% |
| Student > Ph. D. Student | 23 | 12% |
| Student > Postgraduate | 13 | 7% |
| Student > Doctoral Student | 13 | 7% |
| Student > Bachelor | 13 | 7% |
| Other | 42 | 21% |
| Unknown | 64 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 82 | 41% |
| Biochemistry, Genetics and Molecular Biology | 10 | 5% |
| Engineering | 8 | 4% |
| Materials Science | 6 | 3% |
| Chemistry | 5 | 3% |
| Other | 15 | 8% |
| Unknown | 73 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2016.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Biomaterials Research
#142
of 197 outputs
Outputs of similar age
#270,054
of 353,818 outputs
Outputs of similar age from Biomaterials Research
#7
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 197 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,818 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.