Title |
Roles of iron acquisition systems in virulence of extraintestinal pathogenic Escherichia coli: salmochelin and aerobactin contribute more to virulence than heme in a chicken infection model
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Published in |
BMC Microbiology, July 2012
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DOI | 10.1186/1471-2180-12-143 |
Pubmed ID | |
Authors |
Qingqing Gao, Xiaobo Wang, Huiqing Xu, Yaya Xu, Jielu Ling, Debao Zhang, Song Gao, Xiufan Liu |
Abstract |
Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores. Although iron transport systems involved in the pathogenesis of APEC or UPEC have been documented individually in corresponding animal models, the contribution of these systems during simultaneous APEC and UPEC infection is not well described. To determine the contribution of each individual iron acquisition system to the virulence of APEC and UPEC, isogenic mutants affecting iron uptake in APEC E058 and UPEC U17 were constructed and compared in a chicken challenge model. |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
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Demographic breakdown
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Student > Ph. D. Student | 38 | 25% |
Student > Master | 24 | 15% |
Student > Bachelor | 15 | 10% |
Researcher | 14 | 9% |
Student > Doctoral Student | 9 | 6% |
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Other | 14 | 9% |
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