Title |
Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis
|
---|---|
Published in |
Lipids in Health and Disease, July 2012
|
DOI | 10.1186/1476-511x-11-92 |
Pubmed ID | |
Authors |
Ayman Samir Farid, Yoichiro Horii |
Abstract |
The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3, aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. The major goal of this review is to highlight the modulation of each of the PONs by infective (bacterial, viral and parasitic) agents, which may shed a light on the interaction between infectious diseases and PONs activities in order to effectively reduce the risk of developing atherosclerosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Australia | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 60 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 14% |
Student > Master | 9 | 14% |
Researcher | 8 | 13% |
Student > Doctoral Student | 8 | 13% |
Student > Postgraduate | 7 | 11% |
Other | 16 | 25% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 24% |
Agricultural and Biological Sciences | 14 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Other | 8 | 13% |
Unknown | 12 | 19% |