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High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease

Overview of attention for article published in Alzheimer's Research & Therapy, June 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

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26 Dimensions

Readers on

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66 Mendeley
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Title
High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease
Published in
Alzheimer's Research & Therapy, June 2016
DOI 10.1186/s13195-016-0191-0
Pubmed ID
Authors

Malin Degerman Gunnarsson, Martin Ingelsson, Kaj Blennow, Hans Basun, Lars Lannfelt, Lena Kilander

Abstract

Increased concentrations of cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau, as well as decreased amyloid-β 42 peptide, are biomarkers of Alzheimer's disease (AD) pathology, but few studies have shown an association with AD progression rate. We hypothesized that high CSF tau, as a marker of ongoing neurodegeneration, would predict a more aggressive course of AD, using time to nursing home placement (NHP) as the main outcome. Our sample inlcuded 234 patients with mild cognitive impairment (MCI) due to AD (n = 134) or mild to moderate AD (n = 100) who underwent lumbar puncture at a memory clinic and were followed for 2-11 years (median 4.9 years). Individuals with CSF t-tau in the highest quartile (≥900 ng/L) had a higher ratio of NHP, both in the total cohort and in patients with MCI only (adjusted HR 2.17 [95 % CI 1.24-3.80]; HR 2.37 [95 % CI 1.10-5.09], respectively), than the lowest quartile. The association between high t-tau levels and future steep deterioration was confirmed in analyses with conversion to moderate dementia (HR 1.66; 95 % CI 1.08-2.56), rapid decline in Mini Mental State Examination score (≥4-point drop/12 months), and dying in severe dementia as outcomes. To our knowledge, this is the first study to show that high CSF t-tau levels predict early NHP and conversion to moderate dementia in an AD cohort. Selecting patients with high CSF t-tau, indicating more aggressive neurodegeneration and steeper decline, for AD immunotherapy trials might increase the possibility of showing contrast between active treatment and placebo.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 18%
Researcher 9 14%
Student > Ph. D. Student 9 14%
Student > Doctoral Student 6 9%
Other 4 6%
Other 11 17%
Unknown 15 23%
Readers by discipline Count As %
Neuroscience 10 15%
Medicine and Dentistry 10 15%
Psychology 6 9%
Biochemistry, Genetics and Molecular Biology 4 6%
Nursing and Health Professions 4 6%
Other 11 17%
Unknown 21 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2016.
All research outputs
#805,472
of 8,078,414 outputs
Outputs from Alzheimer's Research & Therapy
#141
of 349 outputs
Outputs of similar age
#39,208
of 270,637 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#7
of 14 outputs
Altmetric has tracked 8,078,414 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 349 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.