Title |
Role of the small RNA RyhB in the Fur regulon in mediating the capsular polysaccharide biosynthesis and iron acquisition systems in Klebsiella pneumoniae
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Published in |
BMC Microbiology, July 2012
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DOI | 10.1186/1471-2180-12-148 |
Pubmed ID | |
Authors |
Su-Hua Huang, Chien-Kuo Wang, Hwei-Ling Peng, Chien-Chen Wu, Ying-Tsong Chen, Yi-Ming Hong, Ching-Ting Lin |
Abstract |
The capsular polysaccharide (CPS) and iron acquisition systems are important determinants of Klebsiella pneumoniae infections, and we have previously reported that the ferric uptake repressor (Fur) can play dual role in iron acquisition and CPS biosynthesis. In many bacteria, Fur negatively controls the transcription of the small non-coding RNA RyhB to modulate cellular functions and virulence. However, in K. pneumoniae, the role played by RyhB in the Fur regulon has not been characterised. This study investigated Fur regulation of ryhB transcription and the functional role of RyhB in K. pneumoniae. |
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Mendeley readers
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