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Mendeley readers
Attention Score in Context
| Title |
Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid
|
|---|---|
| Published in |
BMC Musculoskeletal Disorders, July 2012
|
| DOI | 10.1186/1471-2474-13-126 |
| Pubmed ID | |
| Authors |
Bryan J Heard, Liam Martin, Jerome B Rattner, Cyril B Frank, David A Hart, Roman Krawetz |
| Abstract |
Osteoarthritis (OA) and rheumatoid arthritis (RA) are diseases which result in the degeneration of the joint surface articular cartilage. Matrix metalloproteinases (MMPs) are enzymes that aid in the natural remodelling of tissues throughout the body including cartilage. However, some MMPs have been implicated in the progression of OA and RA as their expression levels and activation states can change dramatically with the onset of disease. Yet, it remains unknown if normal and arthritic joints demonstrate unique MMPs expression profiles, and if so, can the MMP expression profile be used to identify patients with early OA. In this study, the synovial fluid protein expression levels for MMPs 1, 2, 3, 7, 8, 9, 12 & 13, as well as those for the Tissue Inhibitors of MMPs (TIMPs) 1, 2, 3, & 4 were examined in highly characterized normal knee joints, and knee joints with clinically diagnosed OA (early and advanced) or RA. The purpose of this study was to determine if normal, OA, and RA patients exhibit unique expression profiles for a sub-set of MMPs, and if early OA patients have a unique MMP expression profile that could be used as an early diagnostic marker. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 77 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Researcher | 12 | 15% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 6 | 8% |
| Professor | 6 | 8% |
| Other | 11 | 14% |
| Unknown | 20 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 33% |
| Agricultural and Biological Sciences | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Engineering | 5 | 6% |
| Nursing and Health Professions | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2012.
All research outputs
#15,247,248
of 22,671,366 outputs
Outputs from BMC Musculoskeletal Disorders
#2,443
of 4,023 outputs
Outputs of similar age
#104,348
of 164,297 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#33
of 51 outputs
Altmetric has tracked 22,671,366 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,023 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,297 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.