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Low-level prenatal lead exposure and infant sensory function

Overview of attention for article published in Environmental Health, June 2016
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  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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6 tweeters
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1 Facebook page
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1 research highlight platform

Citations

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20 Dimensions

Readers on

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78 Mendeley
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Title
Low-level prenatal lead exposure and infant sensory function
Published in
Environmental Health, June 2016
DOI 10.1186/s12940-016-0148-6
Pubmed ID
Authors

Monica K. Silver, Xiaoqing Li, Yuhe Liu, Ming Li, Xiaoqin Mai, Niko Kaciroti, Paul Kileny, Twila Tardif, John D. Meeker, Betsy Lozoff

Abstract

Lead is a pervasive neurotoxicant that has been associated with poorer cognitive, behavioral, and motor outcomes in children. The effects of lead on sensory function have not been well characterized. The aim of this study was to assess the effects of prenatal lead exposure on infant sensory function, as measured by auditory brainstem response (ABR) and grating visual acuity (VA). Lead was measured in maternal blood in mid- and late-pregnancy (mean gestational age = 15.5 and 39.0 weeks, respectively) and umbilical cord blood in a cohort of full-term infants in rural northeastern China. ABR latencies (peaks I, III, V) were measured in newborns during unsedated sleep (n = 315). The ABR central-to-peripheral (C-P) ratio was calculated as the ratio between the III-V and I-III interpeak intervals. VA was measured in 6-week-olds using Teller Acuity Cards (n = 1019) and assigned as the narrowest grid the infant fixated on. Multivariate linear regression was used to evaluate relationships between tertiles of mid-pregnancy, late-pregnancy, or cord lead and newborn ABR or 6-week VA. Higher late-pregnancy lead levels were associated with higher ABR C-P ratios and lower VA. In covariate-adjusted analyses, mean C-P ratios were 4.6 and 3.2 % higher in infants whose mothers had lead > 3.8 μg/dL and lead = 2-3.8 μg/dL, respectively, than for infants whose mothers had lead < 2 μg/dL (p-trend =0.002). In adjusted analyses for VA, mean scores were 8.5 and 7.2 % lower for maternal lead > 3.8 μg/dL and lead = 2-3.8 μg/dL, respectively, compared to lead < 2 μg/dL (p-trend =0.009). Auditory and visual systems maturation appears delayed in infants with higher prenatal lead exposure during late-pregnancy, even at relatively low levels. Both systems start myelinating in late gestation and mature rapidly in infancy. Higher ABR C-P ratio and lower grating VA scores suggest effects of low-level lead exposure on sensory system myelination.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 21%
Student > Master 14 18%
Researcher 9 12%
Student > Ph. D. Student 9 12%
Student > Doctoral Student 5 6%
Other 15 19%
Unknown 10 13%
Readers by discipline Count As %
Nursing and Health Professions 15 19%
Medicine and Dentistry 13 17%
Psychology 9 12%
Environmental Science 5 6%
Social Sciences 4 5%
Other 18 23%
Unknown 14 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#4,931,196
of 17,826,855 outputs
Outputs from Environmental Health
#658
of 1,327 outputs
Outputs of similar age
#79,169
of 273,693 outputs
Outputs of similar age from Environmental Health
#1
of 1 outputs
Altmetric has tracked 17,826,855 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,327 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,693 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them