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Expanding the genetics of amyotrophic lateral sclerosis and frontotemporal dementia

Overview of attention for article published in Alzheimer's Research & Therapy, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

blogs
1 blog
twitter
4 X users

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
26 Mendeley
citeulike
1 CiteULike
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Title
Expanding the genetics of amyotrophic lateral sclerosis and frontotemporal dementia
Published in
Alzheimer's Research & Therapy, July 2012
DOI 10.1186/alzrt133
Pubmed ID
Authors

Jennifer C Schymick, Bryan J Traynor

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized clinically by rapidly progressive paralysis leading ultimately to death from respiratory failure. It is now recognized that ALS and frontotemporal lobar degeneration (FTLD) form a clinical spectrum of disease with overlapping clinical, pathological and genetic features. This past year, the genetic causes of ALS have expanded to include mutations in the genes OPTN, VCP, and UBQLN2, and the hexanucleotide repeat expansion in C9ORF72. The C9ORF72 repeat expansion solidifies the notion that ALS and FTLD are phenotypic variations of a disease spectrum with a common molecular etiology. Furthermore, the C9ORF72 expansion is the genetic cause of a substantial portion of apparently sporadic ALS and FTLD cases, showing that genetics plays a clear role in sporadic disease. Here we describe the progress made in the genetics of ALS and FTLD, including a detailed look at how new insights brought about by C9ORF72 have both broadened and unified current concepts in neurodegeneration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 4%
Colombia 1 4%
Belgium 1 4%
Unknown 23 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 19%
Student > Bachelor 4 15%
Other 3 12%
Student > Master 3 12%
Student > Postgraduate 2 8%
Other 5 19%
Unknown 4 15%
Readers by discipline Count As %
Medicine and Dentistry 7 27%
Agricultural and Biological Sciences 6 23%
Biochemistry, Genetics and Molecular Biology 4 15%
Neuroscience 2 8%
Nursing and Health Professions 1 4%
Other 1 4%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2013.
All research outputs
#3,261,578
of 25,373,627 outputs
Outputs from Alzheimer's Research & Therapy
#791
of 1,464 outputs
Outputs of similar age
#21,427
of 178,780 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#3
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,780 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.