Title |
Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions
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Published in |
Neural Development, January 2012
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DOI | 10.1186/1749-8104-7-4 |
Pubmed ID | |
Authors |
Gonzalo Alvarez-Bolado, Fabian A Paul, Sandra Blaess |
Abstract |
The hypothalamus is a brain region with essential functions for homeostasis and energy metabolism, and alterations of its development can contribute to pathological conditions in the adult, like hypertension, diabetes or obesity. However, due to the anatomical complexity of the hypothalamus, its development is not well understood. Sonic hedgehog (Shh) is a key developmental regulator gene expressed in a dynamic pattern in hypothalamic progenitor cells. To obtain insight into hypothalamic organization, we used genetic inducible fate mapping (GIFM) to map the lineages derived from Shh-expressing progenitor domains onto the four rostrocaudally arranged hypothalamic regions: preoptic, anterior, tuberal and mammillary. |
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