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Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group

Overview of attention for article published in BMC Biology, September 2007
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Title
Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group
Published in
BMC Biology, September 2007
DOI 10.1186/1741-7007-5-39
Pubmed ID
Authors

Thomas Walker, Lisa Klasson, Mohammed Sebaihia, Mandy J Sanders, Nicholas R Thomson, Julian Parkhill, Steven P Sinkins

Abstract

Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes. Species in the Culex pipiens complex display an unusually high number of Wolbachia-induced crossing types, and based on present data, only the wPip strain is present. The sequencing of the wPip strain of Wolbachia revealed the presence of 60 ankyrin repeat domain (ANK) encoding genes and expression studies of these genes were carried out in adult mosquitoes. One of these ANK genes, pk2, is shown to be part of an operon of three prophage-associated genes with sex-specific expression, and is present in two identical copies in the genome. Another homolog of pk2 is also present that is differentially expressed in different Cx. pipiens group strains. A further two ANK genes showed sex-specific regulation in wPip-infected Cx. pipiens group adults. The high number, variability and differential expression of ANK genes in wPip suggest an important role in Wolbachia biology, and the gene family provides both markers and promising candidates for the study of reproductive manipulation.

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The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Germany 1 1%
Brazil 1 1%
United Kingdom 1 1%
Japan 1 1%
Madagascar 1 1%
Unknown 70 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 32%
Researcher 16 21%
Student > Bachelor 9 12%
Student > Master 6 8%
Professor > Associate Professor 4 5%
Other 10 13%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 51 67%
Biochemistry, Genetics and Molecular Biology 8 11%
Environmental Science 4 5%
Immunology and Microbiology 2 3%
Business, Management and Accounting 1 1%
Other 3 4%
Unknown 7 9%