Title |
Low frequency of asymptomatic carriage of toxigenic Clostridium difficile in an acute care geriatric hospital: prospective cohort study in Switzerland
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Published in |
Antimicrobial Resistance & Infection Control, June 2016
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DOI | 10.1186/s13756-016-0123-6 |
Pubmed ID | |
Authors |
Daniela Pires, Virginie Prendki, Gesuele Renzi, Carolina Fankhauser, Valerie Sauvan, Benedikt Huttner, Jacques Schrenzel, Stephan Harbarth |
Abstract |
The role of asymptomatic carriers of toxigenic Clostridium difficile (TCD) in nosocomial cross-transmission remains debatable. Moreover, its relevance in the elderly has been sparsely studied. To assess asymptomatic TCD carriage in an acute care geriatric population. We performed a prospective cohort study at the 296-bed geriatric hospital of the Geneva University Hospitals. We consecutively recruited all patients admitted to two 15-bed acute-care wards. Patients with C. difficile infection (CDI) or diarrhoea at admission were excluded. First bowel movement after admission and every two weeks thereafter were sampled. C. difficile toxin B gene was identified using real-time polymerase chain-reaction (BD MAX(TM)Cdiff). Asymptomatic TCD carriage was defined by the presence of the C. difficile toxin B gene without diarrhoea. A total of 102 patients were admitted between March and June 2015. Two patients were excluded. Among the 100 patients included in the study, 63 were hospitalized and 1 had CDI in the previous year, and 36 were exposed to systemic antibiotics within 90 days prior to admission. Overall, 199 stool samples were collected (median 2 per patient, IQR 1-3). Asymptomatic TCD carriage was identified in two patients (2 %). We found a low prevalence of asymptomatic TCD carriage in a geriatric population frequently exposed to antibiotics and healthcare. Our findings suggest that asymptomatic TCD carriage might contribute only marginally to nosocomial TCD cross-transmission in our and similar healthcare settings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 16% |
Researcher | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Other | 2 | 6% |
Other | 7 | 23% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 32% |
Immunology and Microbiology | 3 | 10% |
Agricultural and Biological Sciences | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 5 | 16% |
Unknown | 9 | 29% |