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Low frequency of asymptomatic carriage of toxigenic Clostridium difficile in an acute care geriatric hospital: prospective cohort study in Switzerland

Overview of attention for article published in Antimicrobial Resistance and Infection Control, June 2016
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3 tweeters

Citations

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4 Dimensions

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28 Mendeley
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Title
Low frequency of asymptomatic carriage of toxigenic Clostridium difficile in an acute care geriatric hospital: prospective cohort study in Switzerland
Published in
Antimicrobial Resistance and Infection Control, June 2016
DOI 10.1186/s13756-016-0123-6
Pubmed ID
Authors

Daniela Pires, Virginie Prendki, Gesuele Renzi, Carolina Fankhauser, Valerie Sauvan, Benedikt Huttner, Jacques Schrenzel, Stephan Harbarth, Pires, Daniela, Prendki, Virginie, Renzi, Gesuele, Fankhauser, Carolina, Sauvan, Valerie, Huttner, Benedikt, Schrenzel, Jacques, Harbarth, Stephan

Abstract

The role of asymptomatic carriers of toxigenic Clostridium difficile (TCD) in nosocomial cross-transmission remains debatable. Moreover, its relevance in the elderly has been sparsely studied. To assess asymptomatic TCD carriage in an acute care geriatric population. We performed a prospective cohort study at the 296-bed geriatric hospital of the Geneva University Hospitals. We consecutively recruited all patients admitted to two 15-bed acute-care wards. Patients with C. difficile infection (CDI) or diarrhoea at admission were excluded. First bowel movement after admission and every two weeks thereafter were sampled. C. difficile toxin B gene was identified using real-time polymerase chain-reaction (BD MAX(TM)Cdiff). Asymptomatic TCD carriage was defined by the presence of the C. difficile toxin B gene without diarrhoea. A total of 102 patients were admitted between March and June 2015. Two patients were excluded. Among the 100 patients included in the study, 63 were hospitalized and 1 had CDI in the previous year, and 36 were exposed to systemic antibiotics within 90 days prior to admission. Overall, 199 stool samples were collected (median 2 per patient, IQR 1-3). Asymptomatic TCD carriage was identified in two patients (2 %). We found a low prevalence of asymptomatic TCD carriage in a geriatric population frequently exposed to antibiotics and healthcare. Our findings suggest that asymptomatic TCD carriage might contribute only marginally to nosocomial TCD cross-transmission in our and similar healthcare settings.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 14%
Student > Ph. D. Student 4 14%
Student > Bachelor 3 11%
Student > Doctoral Student 2 7%
Student > Master 2 7%
Other 7 25%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 9 32%
Immunology and Microbiology 3 11%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 4 14%
Unknown 8 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2016.
All research outputs
#4,136,585
of 7,890,722 outputs
Outputs from Antimicrobial Resistance and Infection Control
#242
of 296 outputs
Outputs of similar age
#145,474
of 268,591 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#12
of 13 outputs
Altmetric has tracked 7,890,722 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 296 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,591 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.