Title |
Imported Crimean-Congo hemorrhagic fever cases in Istanbul
|
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Published in |
BMC Infectious Diseases, June 2007
|
DOI | 10.1186/1471-2334-7-54 |
Pubmed ID | |
Authors |
Kenan Midilli, Ayşen Gargılı, Onder Ergonul, Gönül Şengöz, Recep Ozturk, Mehmet Bakar, Frans Jongejan |
Abstract |
We described a series of imported cases of Crimean-Congo Hemorrhagic Fever (CCHF) in Istanbul and investigated the genetic diversity of the virus. All the suspected cases of CCHF, who were applied to the health centers in Istanbul, were screened for CCHF virus (CCHFv) infection by using semi-nested Polymerase Chain Reaction (PCR) following RT-PCR. Simultaneous blood samples were also sent to the national reference laboratory in Ankara for serologic investigation. In 10 out of 91 patients, CCHFv was detected by PCR, and among 9 out of 10, anti-CCHFv IgM antibodies were also positive. Clinical features were characterized by fever, myalgia, and hemorrhage. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase were elevated, and bleeding markers were prolonged. All the cases were treated with ribavirin. There was no fatal case. All the strains clustered within the same group as other Europe/Turkey isolates. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Uzbekistan | 1 | 2% |
United States | 1 | 2% |
Italy | 1 | 2% |
Unknown | 48 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 23% |
Student > Ph. D. Student | 9 | 17% |
Professor | 5 | 10% |
Student > Bachelor | 4 | 8% |
Professor > Associate Professor | 4 | 8% |
Other | 11 | 21% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 31% |
Agricultural and Biological Sciences | 10 | 19% |
Philosophy | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 6 | 12% |
Unknown | 14 | 27% |