Title |
Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines
|
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Published in |
BMC Molecular and Cell Biology, July 2012
|
DOI | 10.1186/1471-2199-13-25 |
Pubmed ID | |
Authors |
Trinidad Mata Balaguer, Angeles Gómez-Martínez, Pilar García-Morales, Javier Lacueva, Rafael Calpena, Lourdes Rocamora Reverte, Natividad Lopez Riquelme, Isabel Martinez-Lacaci, José A Ferragut, Miguel Saceda |
Abstract |
It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise the use of iHDACs in combination with other cytotoxic agents that are substrates of P-glycoprotein (Pgp). It has also been reported the use of alternative promoters by the ABCB1 gene and the existence of a translational control of Pgp protein. Finally, the ABCB1 gene is located in a genetic locus with the nested gene RUNDC3B in the complementary DNA strand, raising the possibility that RUNDC3B expression could interfere with ABCB1 alternative promoter regulation. |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 88% |
Demographic breakdown
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Student > Ph. D. Student | 3 | 12% |
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Student > Master | 2 | 8% |
Other | 3 | 12% |
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Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 10 | 38% |